Pancreatic mucinous cystadenocarcinoma in a patient harbouring BRCA1 germline mutation effectively treated with olaparib: A case report

Figure 1 Histological examination of the ovarian metastases. A: Hematoxylin-eosin staining (× 10) of the resected specimen showing glandular areas (arrows) next to cystic spaces (stars); B: Higher-power view (× 20) of the glands shown before displaying malignant cytology and an infiltrating pattern.

Figure 2 Magnetic resonance imaging and 18F-fluoro-D-glucose positron emission tomography/X-ray computed tomography. June 2019, Magnetic resonance imaging (MRI) shows the presence of a lesion approximately 4.4 cm × 3.2 cm in the cephalopancreatic area, with MRI characteristics compatible with local recurrence of the basic neoplastic pathology; A: Arterial phase; B: Portal phase; C and D: 18F-fluoro-D-glucose (FDG) positron emission tomography/X-ray computed tomography confirms the diagnostic suspicion of disease recurrence showing a pathological 18F-FDG uptake.

Figure 3 18F-fluoro-D-glucose positron emission tomography/X-ray computed tomography performed after eight courses of FOLFIRINOX. A and B: 18F-fluoro-D-glucose positron emission tomography/X-ray computed tomography shows a metabolic reduction in cephalopancreatic disease.

Figure 4 18F-fluoro-D-glucose positron emission tomography/X-ray computed tomography performed after three months of maintenance olaparib. A and B: 18F-fluoro-D-glucose positron emission tomography/X-ray computed tomography shows complete metabolic normalization of the pancreatic lesion, which is also reduced in size.