©The Author(s) 2017. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2017; 9(2): 62-69
Published online Feb 15, 2017. doi: 10.4251/wjgo.v9.i2.62
Published online Feb 15, 2017. doi: 10.4251/wjgo.v9.i2.62
Circular RNAs in colorectal cancer: Possible roles in regulation of cancer cells
María Isabel Taborda, Sebastián Ramírez, Giuliano Bernal, Laboratory of Molecular and Cell Biology of Cancer (CancerLab), Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, Coquimbo 1781421, Chile
Author contributions: Taborda MI performed the literature review, analysis and article’s writing; Ramírez S provided ideas regarding the conception of this paper and contributed with the graphic design; Bernal G contributed to this paper with a critical revision, editing and approval of the final version.
Conflict-of-interest statement: The authors declare no conflict of interest.
Correspondence to: Giuliano Bernal, PhD, Laboratory of Molecular and Cell Biology of Cancer (CancerLab), Department of Biomedical Sciences, Faculty of Medicine, Universidad Católica del Norte, at Larrondo 1281, Coquimbo 1781421, Chile. gbernal@ucn.cl
Telephone: +56-51-2205988
Received: April 29, 2016
Peer-review started: May 4, 2016
First decision: July 20, 2016
Revised: November 5, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: February 15, 2017
Processing time: 291 Days and 11 Hours
Peer-review started: May 4, 2016
First decision: July 20, 2016
Revised: November 5, 2016
Accepted: December 13, 2016
Article in press: December 14, 2016
Published online: February 15, 2017
Processing time: 291 Days and 11 Hours
Core Tip
Core tip: Circular RNAs (circRNAs) are noncoding RNAs, characterized for its circularized shape. These circRNAs are abundant and might play important roles in cancer. In particular, they exhibit altered expression in colorectal cancer, and its activity as miRNA sponge might be involved in the control of cancer progression. Moreover, owing to their stability, could serve as diagnostic or predictive biomarkers for colorectal cancer.