©The Author(s) 2016. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Sep 15, 2016; 8(9): 673-681
Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.673
Published online Sep 15, 2016. doi: 10.4251/wjgo.v8.i9.673
Molecular mechanisms of chemoresistance in gastric cancer
Wen-Jia Shi, Department of Pediatric Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Jin-Bo Gao, Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430022, Hubei Province, China
Author contributions: Shi WJ and Gao JB contributed equally to this work.
Supported by National Natural Science Foundation of China , No. 81572411 .
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Correspondence to: Dr. Jin-Bo Gao, Associate Professor, Department of Gastrointestinal Surgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Avenue, Wuhan 430022, Hubei Province, China. gaojinbo@163.com
Telephone: +86-27-85351619 Fax: +86-27-85351619
Received: March 27, 2016
Peer-review started: March 28, 2016
First decision: May 23, 2016
Revised: June 7, 2016
Accepted: June 27, 2016
Article in press: June 29, 2016
Published online: September 15, 2016
Processing time: 168 Days and 13.6 Hours
Peer-review started: March 28, 2016
First decision: May 23, 2016
Revised: June 7, 2016
Accepted: June 27, 2016
Article in press: June 29, 2016
Published online: September 15, 2016
Processing time: 168 Days and 13.6 Hours
Core Tip
Core tip: Although chemotherapy remains one of the primary therapeutic modalities used in the treatment of gastric cancer, chemoresistance limits the effectiveness of chemotherapy and results in treatment failure. The elucidation of the mechanisms of drug resistance will be very helpful for the prediction of sensitivity to chemotherapy and the reversal of drug resistance to improve therapeutic efficacy. The mechanisms of drug resistance have been broadly investigated in recent years. In this review, we summarize the molecular mechanisms of chemoresistance in gastric cancer and discuss the progress in the reversal of drug resistance.