Gastric cancer development after the successful eradication of Helicobacter pylori

Core Tip

Core tip: Since the indication for eradication therapy for Helicobacter pylori became widespread, the number of gastric cancer (GC) cases that emerge after eradication has continued to increase. However, the underlying mechanism of restoration/carcinogenesis in the gastric mucosa after eradication therapy has not been fully elucidated. We previously demonstrated that, instead of conventional endoscopy, Congo-red chromoendoscopy might be more precise in its ability to identify the multi-focal distribution of functionally irreversible mucosa that may be present in individuals with high risk for GC even after successful eradication. Further research using functional imaging may provide new insights to address the mechanism of gastric regeneration/carcinogenesis, and subsequently, may allow for the development of biomarkers for GC in high risk individuals during post-eradication surveillance.