©The Author(s) 2015. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2015; 7(10): 178-183
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.178
Published online Oct 15, 2015. doi: 10.4251/wjgo.v7.i10.178
Fecal DNA testing for colorectal cancer screening: Molecular targets and perspectives
Amaninder Dhaliwal, Panagiotis J Vlachostergios, Katerina G Oikonomou, Department of Medicine, NYU Lutheran Medical Center, Brooklyn, NY 11220, United States
Yitzchak Moshenyat, Division of Gastroenterology, NYU Lutheran Medical Center, Brooklyn, NY 11220, United States
Author contributions: Dhaliwal A and Vlachostergios PJ contributed equally to this work; Dhaliwal A and Vlachostergios PJ designed research; Dhaliwal A, Vlachostergios PJ and Oikonomou KG performed research and analyzed data; Dhaliwal A and Vlachostergios PJ wrote the paper; and Moshenyat Y revised the paper.
Conflict-of-interest statement: There is no conflict of interest related to this paper.
Correspondence to: Panagiotis J Vlachostergios, MD, PhD, Department of Medicine, NYU Lutheran Medical Center, 150 55th Street, Brooklyn, NY 11220, United States. panagiotis.vlachostergios@nyumc.org
Telephone: +1-718-6306345 Fax: +1-718-2105306
Received: April 28, 2015
Peer-review started: May 7, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: August 25, 2015
Article in press: August 28, 2015
Published online: October 15, 2015
Processing time: 173 Days and 20.8 Hours
Peer-review started: May 7, 2015
First decision: June 2, 2015
Revised: June 17, 2015
Accepted: August 25, 2015
Article in press: August 28, 2015
Published online: October 15, 2015
Processing time: 173 Days and 20.8 Hours
Core Tip
Core tip: The molecular DNA targets from genetic and epigenetic alterations hallmarking colorectal carcinogenesis are reviewed here in the context of fecal testing. Also, comparison with other screening methods in terms of limitations, advantages and future perspectives of fecal DNA tests are discussed.