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©2014 Baishideng Publishing Group Co., Limited. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2014; 6(1): 1-10
Published online Jan 15, 2014. doi: 10.4251/wjgo.v6.i1.1
Published online Jan 15, 2014. doi: 10.4251/wjgo.v6.i1.1
Approaches that ascertain the role of dietary compounds in colonic cancer cells
Michael Bordonaro, Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA 18509, United States
Koen Venema, TNO, Research group Kinetics Research for Food and Pharma, Zeist 3700 AJ, The Netherlands
Adeline K Putri, Maastricht University, Health Food Innovation Management, Campus Venlo, Venlo 5911 AA, The Netherlands
Darina Lazarova, Department of Basic Sciences, The Commonwealth Medical College, Scranton, PA 18509, United States
Supported by NIH grants Acknowledges the Support of the European Science Foundation, in the framework of the Research Networking Program, No. R15CA152852-01; The European Network for Gastrointestinal Health Research, No. R15CA149589-01
Author contributions: All authors contributed equally to this work.
Correspondence to: Darina Lazarova, PhD, Associate Professor, Department of Basic Sciences, The Commonwealth Medical College, 525 Pine Street, Scranton, PA 18509, United States. dlazarova@tcmedc.org
Telephone: +1-57-5049645 Fax: +1-57-5049636
Received: October 4, 2013
Revised: November 26, 2013
Accepted: December 17, 2013
Published online: January 15, 2014
Processing time: 117 Days and 11.8 Hours
Revised: November 26, 2013
Accepted: December 17, 2013
Published online: January 15, 2014
Processing time: 117 Days and 11.8 Hours
Core Tip
Core tip: Studies on diet and colorectal cancer are in their infancy, and the relevance of many publications on the topic is questionable due to three problems: (1) there is uncertainty about which diet-derived compounds are present in the colon; (2) most studies have focused on individual bioactives; whereas, food intake results in complex metabolite mixtures; and (3) the physiological concentrations of many colonic bioactives are unknown. Here we discuss how the use of fecal water samples and in vitro models of human colon address these problems.