Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Sep 15, 2026; 18(9): 121675
Published online Sep 15, 2026. doi: 10.4251/wjgo.121675
Published online Sep 15, 2026. doi: 10.4251/wjgo.121675
Retrospective analysis of risk factors for leftsided vs rightsided colon cancer in a southern Chinese Han population
Yu Lai, Ying Lin, Qi-Kui Chen, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Yan-Fang Ye, Division of Clinical Research Design, Clinical Research Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou 510120, Guangdong Province, China
Yun-Fang Yu, Guangdong Provincial Key Laboratory of Cancer Pathogenesis and Precision Diagnosis and Treatment, Shenshan Medical Center, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Shanwei 510120, Guangdong Province, China
Co-first authors: Yu Lai and Yan-Fang Ye.
Author contributions: Lai Y and Lin Y were responsible for conceptualization, methodology, resources, and writing; Lai Y were responsible for validation and investigation; Lai Y and Ye YF were responsible for software, data curation, formal analysis and project administration and they contribute equally to this study as co-first authors; Lin Y and Chen QK were responsible for writing - review, editing, visualization, and supervision; Yu YF was responsible for funding acquisition; all authors have read and agreed to the published version of the manuscript.
Supported by Guangdong Province’s 2024 Annual Key Laboratory Project, No. 2024B1212030002.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Board Institutional Review Board Committee at Sun Yat-Sen Memorial Hospital, Sun Yat-Sen University (Approved No. SYSKY-2026-377-01).
Informed consent statement: Patient consent was waived due to the retrospective nature of the study and the analysis used anonymous clinical data.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: The data presented in this study are available on request from the corresponding author.
Corresponding author: Ying Lin, Department of Gastroenterology, Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No 107 Yanjiangxi Road, Yuexiu District, Guangzhou 510120, Guangdong Province, China. linwy@mail.sysu.edu.cn
Received: April 1, 2026
Revised: April 29, 2026
Accepted: June 16, 2026
Published online: September 15, 2026
Processing time: 148 Days and 1.3 Hours
Revised: April 29, 2026
Accepted: June 16, 2026
Published online: September 15, 2026
Processing time: 148 Days and 1.3 Hours
Core Tip
Core Tip: This is a retrospective study that identifies distinct risk profiles for left-sided and right-sided colorectal cancer within the southern Chinese Han population. The findings reveal that screening strategies in specific location, informed by metabolic and lifestyle factors, are crucial for improving early detection and prognosis, especially in this underrepresented cohort.