Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Sep 15, 2026; 18(9): 120559
Published online Sep 15, 2026. doi: 10.4251/wjgo.120559
Published online Sep 15, 2026. doi: 10.4251/wjgo.120559
Comparative study of 18F-FAPI-04 and 18F-FDG PET/CT in the initial staging and postoperative metastasis detection of gastric cancer
Xiu-Qing Xue, Ran Wang, Xun Shi, Department of Nuclear Medicine, The First People’s Hospital of Yancheng, Yancheng 224006, Jiangsu Province, China
Xiu-Qing Xue, Ran Wang, Xun Shi, Department of Nuclear Medicine, The Yancheng Clinical College of Xuzhou Medical University, Yancheng 224006, Jiangsu Province, China
Qing-Bo Li, Hai-Tian Fu, Lu Hou, Chun-Jing Yu, Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University, Wuxi 214000, Jiangsu Province, China
Co-first authors: Xiu-Qing Xue and Qing-Bo Li.
Author contributions: Xue XQ and Li QB conceived the idea for the manuscript, acquired and analyzed experimental data, and drafted and revised the manuscript, they contributed equally to this article, they are the co-first authors of this manuscript; Fu HT and Hou L acquired experimental data; Wang R and Shi X analyzed experimental data; Yu CJ wrote the manuscript; Fu HT, Hou L, Wang R, Shi X, and Yu CJ contributed to the study design and manuscript revision; and all authors have read and approved the final version of the manuscript.
AI contribution statement: The core contents of this document, including point-to-point replies to reviewers’ comments, academic explanations and revision statements, are all written independently by the authors. Only a small number of sentences were preliminarily drafted and expressions adjusted with AI assistance. AI tools were merely used for partial translation and language polishing to improve English writing fluency. All contents revised with AI assistance have been fully reviewed and verified sentence by sentence by the authors to ensure academic accuracy and rigorous logical thinking.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Affiliated Hospital of Jiangnan University, approval No. LSX2022043.
Clinical trial registration statement: This clinical trial was registered at ClinicalTrials.gov (registration No. NCT05691894; URL: https://clinicaltrials.gov/study/NCT05691894).
Informed consent statement: All patients/participants (or their legal guardians) provided written informed consent prior to their participation in this study. The consent covered the use of their data and samples for research purposes and publication.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No additional data are available.
Corresponding author: Chun-Jing Yu, DM, Chief Physician, Department of Nuclear Medicine, Affiliated Hospital of Jiangnan University, No. 1000 Hefeng Road, Wuxi 214000, Jiangsu Province, China. ycjwxd1978@jiangnan.edu.cn
Received: March 2, 2026
Revised: May 12, 2026
Accepted: June 24, 2026
Published online: September 15, 2026
Processing time: 177 Days and 6.4 Hours
Revised: May 12, 2026
Accepted: June 24, 2026
Published online: September 15, 2026
Processing time: 177 Days and 6.4 Hours
Core Tip
Core Tip: This prospective pilot study compares 18F-fibroblast activation protein inhibitor-04 and 18F-fluorodeoxyglucose positron emission tomography/computed tomography in 21 gastric cancer (GC) patients. 18F-fibroblast activation protein inhibitor-04 shows higher uptake, contrast and tumor-burden estimates in primary GC, peritoneal and bone metastases, and higher sensitivity in detecting lymph node and peritoneal metastases, suggesting its potential value for initial staging and postoperative assessment in GC.