Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Sep 15, 2026; 18(9): 118614
Published online Sep 15, 2026. doi: 10.4251/wjgo.118614
Published online Sep 15, 2026. doi: 10.4251/wjgo.118614
Multidimensional integration: A novel breakthrough in prognostic prediction for immunochemotherapy in human epidermal growth factor receptor-2-negative advanced gastric cancer
Meng-Fan Li, Graduate School, Hebei North University, The Eighth Medical Center of People’s Liberation Army General Hospital, Beijing 100019, China
Song-Nan Du, Department of Radiation Oncology, the Fifth Medical Center of Chinese PLA General Hospital, Beijing 100019, China
Peng-Tao Bao, Department of Respiratory and Critical Care Medicine, The Eighth Medical Center of People’s Liberation Army General Hospital, Beijing 100019, China
Yu-Geng Li, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), Qingdao 266033, Shandong Province, China
Co-first authors: Meng-Fan Li and Song-Nan Du.
Author contributions: Li MF and Du SN drafted the initial manuscript, and they contributed equally to this manuscript as co-first authors; Bao PT contributed to clinical data acquisition; Li YG supervised the overall study, reviewed and edited the manuscript, and approved the final version. All authors read and approved the final manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Yu-Geng Li, Qingdao Hiser Hospital Affiliated of Qingdao University (Qingdao Traditional Chinese Medicine Hospital), No. 4 Renmin Road, Shibei District, Qingdao 266033, Shandong Province, China. qq252656554@163.com
Received: January 7, 2026
Revised: January 31, 2026
Accepted: March 6, 2026
Published online: September 15, 2026
Processing time: 231 Days and 0.2 Hours
Revised: January 31, 2026
Accepted: March 6, 2026
Published online: September 15, 2026
Processing time: 231 Days and 0.2 Hours
Core Tip
Core Tip: Multidimensional prognostic models integrating molecular, clinical, and host-related factors represent a promising approach for predicting outcomes in human epidermal growth factor receptor-2 negative advanced gastric cancer undergoing immunochemotherapy. Despite encouraging progress, challenges remain regarding model generalizability, biomarker standardization, and clinical applicability. Future integration of multi-omics data and artificial intelligence may enable more precise and dynamic prediction systems.