Advances in molecular mechanism of gastric cancer peritoneal metastasis

doi:10.4251/wjgo.v18.i8.121799

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Aug 15, 2026; 18(8): 121799
Published online Aug 15, 2026. doi: 10.4251/wjgo.v18.i8.121799

Advances in molecular mechanism of gastric cancer peritoneal metastasis

Hai-Qing Yan, Qin-Qiao Lai, Ming-Wei Huang, Ting-An Wang, Liu-Cheng Wu, Yu-Zhou Qin

Hai-Qing Yan, Ming-Wei Huang, Ting-An Wang, Liu-Cheng Wu, Yu-Zhou Qin, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Qin-Qiao Lai, Department of Hematology/Oncology, Guangxi Medical University Cancer Hospital, Nanning 530021, Guangxi Zhuang Autonomous Region, China

Author contributions: All authors made substantial contributions to the conception or design of the work. Qin YZ developed the concept for the review; Lai QQ, Huang MW, Wang TA, and Wu LC performed the literature search and interpretation; Yan HQ drafted the work. All authors critically reviewed, edited and revised the manuscript, and approved the final draft for submission.

AI contribution statement: This paper used the DeepSeek AI tool for writing assistance. No part of this paper, in whole or in part, was generated by AI. This paper used DeepSeek for sentence optimization during its writing. However, the author takes full responsibility for the academic content and views in the entire text. AI tools were not involved in the research design. There are no AI-generated images in the manuscript.

Supported by National Natural Science Foundation of China, No. 82360593; Joint Project on Regional High-Incidence Diseases Research of Guangxi Natural Science Foundation, No. 2023GXNSFAA026133; Guangxi Key Research and Development Program, No. guikeAB24010097; and First-Class Discipline Innovation-Driven Talent Program of Guangxi Medical University.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Yu-Zhou Qin, Department of Gastrointestinal Surgery, Guangxi Medical University Cancer Hospital, Lianyu Avenue, Nanning 530021, Guangxi Zhuang Autonomous Region, China. qyz402@126.com

Received: April 2, 2026
Revised: April 17, 2026
Accepted: May 25, 2026
Published online: August 15, 2026
Processing time: 128 Days and 7.5 Hours

Core Tip

Core Tip: Gastric cancer peritoneal metastasis involves multiple complex biological processes. These include genetic mutations, epithelial-mesenchymal transition, extracellular matrix remodeling, tumor microenvironment interactions, hypoxia-driven responses, anoikis resistance, metabolic reprogramming, and epigenetic regulation. This review systematically elucidates the synergistic interactions among these networks. It also highlights their potential as diagnostic biomarkers and therapeutic targets.