Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120486
Published online Aug 15, 2026. doi: 10.4251/wjgo.120486
Published online Aug 15, 2026. doi: 10.4251/wjgo.120486
Impact of combined pregabalin and multimodal analgesia on cancer pain and quality of life in advanced colorectal cancer
Xiao-Yu Wang, Zhan-Dong Wang, Kuo Kan, Xin-Xin Guo, Department of Pain Medicine, The Third Affiliated Hospital of Jinzhou Medical University, Jinzhou 121000, Liaoning Province, China
Co-first authors: Xiao-Yu Wang and Zhan-Dong Wang.
Author contributions: Wang XY designed the research, collected and analyzed the data, and drafted the manuscript; Wang XY and Wang ZD contributed equally to this article, they are the co-first authors of this manuscript; Wang ZD and Guo XX conceptualized the research and applied for the funding; Kan K revised the manuscript critically, coordinated communications, conducted the ethical review, handled copyright and licensing matters, and managed the follow-up work; and all authors have read and approved the final version of the manuscript.
Supported by Liaoning Provincial Science and Technology Joint Plan Project, No. 2023-MSLH-051.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Third Affiliated Hospital of Jinzhou Medical University, approval No. JYDSY-KXYJ-IEC-2026-007.
Clinical trial registration statement: This study has not yet been registered with clinical trials.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CONSORT 2010 statement: The authors have read the CONSORT 2010 Statement, and the manuscript was prepared and revised according to the CONSORT 2010 Statement.
Data sharing statement: No other data available.
Corresponding author: Xin-Xin Guo, Associate Chief Physician, Department of Pain Medicine, The Third Affiliated Hospital of Jinzhou Medical University, No. 2 Section 5 Heping Road, Linghe District, Jinzhou 121000, Liaoning Province, China. mzguoxx@163.com
Received: February 27, 2026
Revised: March 20, 2026
Accepted: May 9, 2026
Published online: August 15, 2026
Processing time: 160 Days and 17.8 Hours
Revised: March 20, 2026
Accepted: May 9, 2026
Published online: August 15, 2026
Processing time: 160 Days and 17.8 Hours
Core Tip
Core Tip: This study verifies that pregabalin combined with routine multimodal analgesia exerts a certain analgesic effect in advanced colorectal cancer patients with moderate-severe cancer pain, effectively reducing breakthrough pain and opioid dosage, significantly improving patients’ quality of life, with manageable adverse reactions, thus holding high clinical application value.