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World J Gastrointest Oncol. Aug 15, 2026; 18(8): 120005
Published online Aug 15, 2026. doi: 10.4251/wjgo.120005
Published online Aug 15, 2026. doi: 10.4251/wjgo.120005
Integration of cytogenetic aberrations and in silico pathway enrichment identifies novel candidate genes in esophageal squamous cell carcinoma
Jagjeet Kaur, Department of Infectious Disease, Henry Ford Health, Detroit, MI 48202, United States
Jagjeet Kaur, Vasudha Sambyal, Kamlesh Guleria, Department of Human Genetics, Guru Nanak Dev University, Amritsar 143005, Punjab, India
Manjit Singh Uppal, Department of Surgery, Sri Guru Ram Das University of Health Sciences Sri Amritsar, Amritsar 143005, Punjab, India
Meena Sudan, Department of Radiotherapy, Sri Guru Ram Das University of Health Sciences Sri Amritsar, Amritsar 143005, Punjab, India
Author contributions: Kaur J carried out experimental work, literature research, data acquisition and analysis, statistical analysis, and manuscript preparation; Kaur J, Sambyal V and Guleria K were responsible for manuscript editing and reviewing; Sambyal V and Guleria K participated in the study design; Uppal MS and Sudan M provided the clinical details of the patients; all authors read and approved the final manuscript.
AI contribution statement: No AI tools were used in preparation of the response to reviewers. AI did not participate in study design or interpretation of the results.
Institutional review board statement: The study was reviewed and approved by the Institutional Ethical Committee of Guru Nanak Dev University, Amritsar, India.
Informed consent statement: All participants provided informed consent.
Conflict-of-interest statement: The authors have no conflicts of interest to declare.
STROBE statement: The authors have read the STROBE Statement – checklist of items, and the manuscript was prepared and revised according to the STROBE Statement – checklist of items.
Data sharing statement: Datasets are available from the corresponding author for sharing upon reasonable request
Corresponding author: Jagjeet Kaur, PhD, Department of Human Genetics, Guru Nanak Dev University, Grand Trunk Road, Amritsar 143005, Punjab, India. jagjeet30.jb@gmail.com
Received: February 14, 2026
Revised: March 10, 2026
Accepted: June 4, 2026
Published online: August 15, 2026
Processing time: 170 Days and 19.2 Hours
Revised: March 10, 2026
Accepted: June 4, 2026
Published online: August 15, 2026
Processing time: 170 Days and 19.2 Hours
Core Tip
Core Tip: This study highlights the role of chromosomal instability in esophageal cancer. By analyzing 135 patients, researchers found significantly higher chromosomal aberrations compared to controls. In silico analysis identified key genes like signal transducer and activator of transcription 3 and tumor protein p53, plus 12 genes enriched in the RNA polymerase II pathway. These findings reveal new genetic markers, offering deeper insights into esophageal cancer development and progression.