Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. Aug 15, 2026; 18(8): 119679
Published online Aug 15, 2026. doi: 10.4251/wjgo.119679
Published online Aug 15, 2026. doi: 10.4251/wjgo.119679
Multidisciplinary care for colorectal cancer brain metastases with headache as initial symptom: A case report and literature review
Jia-Lu Xu, Zhen-Wei Ge, Chang-Wei Wu, Yu-Hao Wang, Jia-Ding Mao, Department of Gas
Co-first authors: Jia-Lu Xu and Zhen-Wei Ge.
Author contributions: Xu JL and Ge ZW conceptualized and drafted the manuscript, and performed its full revision, and they contributed equally to this article as co-first authors; Wu CW was responsible for picture collection; Wang YH revised the final manuscript; and all authors have read and approved the final version of the manuscript.
AI contribution statement: AI tools were used solely for linguistic refinement. No AI tool was involved in the generation of research data, interpretation of results, or formulation of conclusions. All AI-generated outputs were critically reviewed and revised by the authors.
Supported by Provincial Financial Support Project/Key Project of Health Commission of Anhui Province, No. AHWJ2023A10136; and the Anhui Provincial Clinical Medical Research Transformation Project, No. 202527c10020099.
Informed consent statement: Informed verbal consent was obtained from the patient's families for publication of this report and any accompanying images.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Corresponding author: Jia-Ding Mao, PhD, Professor, Department of Gastrointestinal Surgery, Yijishan Hospital of Wannan Medical University, No. 2 Zheshan West Road, Wuhu 241000, Anhui Province, China. 20111575@wnmc.edu.cn
Received: February 3, 2026
Revised: March 14, 2026
Accepted: May 9, 2026
Published online: August 15, 2026
Processing time: 182 Days and 2.2 Hours
Revised: March 14, 2026
Accepted: May 9, 2026
Published online: August 15, 2026
Processing time: 182 Days and 2.2 Hours
Core Tip
Core Tip: Given the rarity of brain metastasis from colorectal cancer in the absence of extracranial spread or typical gastrointestinal symptoms, few such cases have been reported, and clinicians have limited diagnostic and therapeutic experience with this condition. This article presents a case of colorectal cancer brain metastasis and summarizes the diagnostic challenges and multidisciplinary treatment strategy for this disease.