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World J Gastrointest Oncol. Aug 15, 2026; 18(8): 119432
Published online Aug 15, 2026. doi: 10.4251/wjgo.119432
Published online Aug 15, 2026. doi: 10.4251/wjgo.119432
Association between preoperative neutrophil-to-lymphocyte ratio and malignant intraductal papillary mucinous neoplasms: A systematic review and meta-analysis
Wen-Wen Dong, Li-Li Zhou, Du-Jiang Yang, Division of Pancreatic Surgery, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Wen-Wen Dong, Li-Li Zhou, West China School of Nursing, Sichuan University, Chengdu 610041, Sichuan Province, China
Hui-Min Lu, Department of General Surgery, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Hui-Min Lu, West China Center of Excellence for Pancreatitis, Institute of Integrated Traditional Chinese and Western Medicine, West China Hospital, Sichuan University, Chengdu 610041, Sichuan Province, China
Author contributions: Dong WW and Zhou LL performed the literature search and data extraction; Dong WW, Zhou LL, and Yang DJ analyzed the data and drafted the manuscript; Lu HM conceived and designed the study and critically revised the manuscript; and all authors approved the final version of the manuscript.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
PRISMA 2009 Checklist statement: The authors have read the PRISMA 2009 Checklist, and the manuscript was prepared and revised according to the PRISMA 2009 Checklist.
Corresponding author: Hui-Min Lu, MD, PhD, Associate Professor, Department of General Surgery, West China Hospital, Sichuan University, No. 37 Guoxue Alley, Chengdu 610041, Sichuan Province, China. hm.lu@scu.edu.cn
Received: January 28, 2026
Revised: April 1, 2026
Accepted: May 7, 2026
Published online: August 15, 2026
Processing time: 187 Days and 11.3 Hours
Revised: April 1, 2026
Accepted: May 7, 2026
Published online: August 15, 2026
Processing time: 187 Days and 11.3 Hours
Core Tip
Core Tip: This meta-analysis suggests that an elevated preoperative neutrophil-to-lymphocyte ratio (NLR) is associated with malignant intraductal papillary mucinous neoplasm. As an inexpensive and readily available inflammatory marker, the NLR may assist in preoperative risk stratification. However, because of study heterogeneity and the nonspecific nature of the NLR, it should be considered an adjunctive marker rather than a standalone predictor.