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World J Gastrointest Oncol. Aug 15, 2026; 18(8): 119026
Published online Aug 15, 2026. doi: 10.4251/wjgo.119026
Published online Aug 15, 2026. doi: 10.4251/wjgo.119026
Polymerase chain reaction detection of Streptococcus anginosus in digestive diseases and its immunomodulation in rat gastric cancer model
Dong-Biao Huang, Xiu-Zhen Hu, Clinical Laboratory, Panan County People’s Hospital, Jinhua 322300, Zhejiang Province, China
Bai-Song Chen, Department of Surgery, Panan County People’s Hospital, Jinhua 322300, Zhejiang Province, China
Ai-Ping Wang, Department of Pediatrics, Panan County People’s Hospital, Jinhua 322300, Zhejiang Province, China
Ye-Jin Xu, Department of Infectious Diseases, Jinhua Municipal Central Hospital, Jinhua 321000, Zhejiang Province, China
Author contributions: Huang DB and Chen BS has been involved in drafting the manuscript, designed the research study; Huang DB, Wang AP, Hu XZ and Xu YJ performed the research; Wang AP and Hu XZ collected and analyzed the data; all authors have been involved in revising manuscript critically for important intellectual content, participated sufficiently in the work to take public responsibility for appropriate portions of the content and agreed to be accountable for all aspects of the work in ensuring that questions related to its accuracy or integrity, give final approval of the version to be published.
AI contribution statement: The answering-reviewers has been accurately translated into English and has been polished using translation software. No data analysis or writing assistance was conducted.
Institutional review board statement: The study was reviewed and approved by the Institutional Review Boards of Panan County People’s Hospital, No. 2024-105.
Institutional animal care and use committee statement: All procedures involving animals were reviewed and approved by the Institutional Animal Care and Use Committee of the of Biomedical Analysis and Testing Center, National University Science Park, Zhejiang University, No. SYXK (Yue)20250398.
Conflict-of-interest statement: All authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: There is no additional data available.
Corresponding author: Ye-Jin Xu, Chief Physician, Department of Infectious Diseases, Jinhua Municipal Central Hospital, No. 365 Renmin East Road, Jinhua 321000, Zhejiang Province, China. xuyejinfox@163.com
Received: February 6, 2026
Revised: March 11, 2026
Accepted: June 22, 2026
Published online: August 15, 2026
Processing time: 177 Days and 12.5 Hours
Revised: March 11, 2026
Accepted: June 22, 2026
Published online: August 15, 2026
Processing time: 177 Days and 12.5 Hours
Core Tip
Core Tip: This study characterizes Streptococcus anginosus (S. anginosus) colonization across digestive diseases and its immunomodulatory role in gastric cancer. In a prospective cohort of 93 patients, S. anginosus positivity and relative load were highest in malignant tumors. Using a chemically induced gastric cancer rat model, S. anginosus colonization was shown to promote tumor progression, elevate serum interleukin-6 and tumor necrosis factor-α levels, and enhance infiltration of CD4+, CD8+ T cells, and CD68+ macrophages. The findings indicate that S. anginosus remodels the tumor immune microenvironment to favor carcinogenesis, suggesting its potential as a microbial and immunotherapeutic target.