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World J Gastrointest Oncol. Jun 15, 2026; 18(6): 120263
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.120263
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.120263
Reframing endoscopic screening in upper gastrointestinal cancers: From early detection to precision primary prevention
Jing Shi, Department of Third Operation Room, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yun-Dong Shi, Department of Nephropathy, Jilin People’s Hospital, Jilin City Hospital, Jilin City 132000, Jilin Province, China
Ying-Hui Chen, Department of General Surgery, Jiutai People’s Hospital, Changchun 130500, Jilin Province, China
Co-corresponding authors: Yun-Dong Shi and Ying-Hui Chen.
Author contributions: Shi J conceived and designed the study, performed the literature review, and drafted the initial manuscript; Shi YD contributed to conceptual development, critical revision of the manuscript, and supervision of the study; Chen YH participated in literature screening, manuscript revision, and final approval of the version to be published; Shi YD and Chen YH are co-corresponding authors and contributed equally to the supervision of the study and correspondence of the manuscript; all authors have read and approved the final manuscript.
AI contribution statement: ChatGPT was used only for language polishing and writing assistance at the level of grammar and expression improvement. It was not used for data analysis or scientific content generation. The main text content was independently written by us, and no AI was used in study design. All figures and tables were created by ourselves.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Yun-Dong Shi, MD, Professor, Department of Nephropathy, Jilin People’s Hospital, Jilin City Hospital, Zhongxing Street, Jilin City 132000, Jilin Province, China. drshiyundong@163.com
Received: February 24, 2026
Revised: March 2, 2026
Accepted: March 24, 2026
Published online: June 15, 2026
Processing time: 107 Days and 21.8 Hours
Revised: March 2, 2026
Accepted: March 24, 2026
Published online: June 15, 2026
Processing time: 107 Days and 21.8 Hours
Core Tip
Core Tip: Endoscopic screening for upper gastrointestinal cancers has traditionally been regarded as a secondary prevention tool focused on early detection. Emerging evidence suggests that screening participation may facilitate behavioral risk modification and enhanced risk awareness, suggesting a potential paradigm shift toward precision primary prevention. By integrating behavioral intervention, risk stratification, and digital follow-up into structured screening pathways, endoscopic programs can evolve into multidimensional prevention platforms that reduce long-term cancer risk and improve population-level cancer control.