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World J Gastrointest Oncol. Jun 15, 2026; 18(6): 117582
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117582
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117582
Prognostic significance of baseline C-reactive protein/albumin ratio for long-term outcomes in advanced gastric cancer under immunochemotherapy
Shuai Mei, Mei-Ling Ye, Qiu-Lin Hao, Geng-Chen Li, Zhi-Yuan Yao, Hai-Yan Wang, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou 221000, Jiangsu Province, China
Co-first authors: Shuai Mei and Mei-Ling Ye.
Co-corresponding authors: Zhi-Yuan Yao and Hai-Yan Wang.
Author contributions: Mei S, Ye ML, Yao ZY, and Wang HY contributed to the conceptualization, writing-review and editing of this manuscript, and the project administration and the supervision of this manuscript; Mei S and Wang HY were responsible for the methodology of this study; Mei S and Ye ML contributed to the formal analysis of this manuscript and the visualization of this article, responsible for the validation of this manuscript; Mei S, Ye ML, and Hao QL took part in the writing-original draft and investigation of this manuscript; Hao QL and Li GC took part in the data curation of this study; Li GC took part in the resources; Yao ZY and Wang HY were involved in the supervision of this study; Mei S and Ye ML contributed equally to the manuscript, they are co-first authors of this manuscript; Yao ZY and Wang HY contributed to this manuscript equally, they are co-corresponding authors of this study.
AI contribution statement: No entirety or any portion of the main text was AI-generated. All content was independently written by the authors. Only ChatGPT was used for language polishing and grammatical revision, not for full-text translation or manuscript writing. No AI tool participated in the study design, data analysis or interpretation of results. All figures and images in the manuscript are original experimental results of the authors, and no images were generated by AI.
Institutional review board statement: This research was carried out following the Declaration of Helsinki and received approval from the Ethics Committee at the Affiliated Hospital of Xuzhou Medical University (approval No. XYFY2025-KL385-01).
Informed consent statement: Given the retrospective design of this investigation, the Ethics Committee of the Affiliated Hospital of Xuzhou Medical University granted us an exemption from obtaining written informed consent.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: Technical appendix, statistical code, and dataset available from the corresponding author at xzhaiyan68@163.com. Participants gave informed consent for data sharing.
Corresponding author: Hai-Yan Wang, MD, Doctor, Department of Oncology, The Affiliated Hospital of Xuzhou Medical University, No. 99 Huaihai West Road, Quanshan District, Xuzhou 221000, Jiangsu Province, China. xzhaiyan68@163.com
Received: December 11, 2025
Revised: January 5, 2026
Accepted: January 27, 2026
Published online: June 15, 2026
Processing time: 181 Days and 1.7 Hours
Revised: January 5, 2026
Accepted: January 27, 2026
Published online: June 15, 2026
Processing time: 181 Days and 1.7 Hours
Core Tip
Core Tip: The baseline C-reactive protein/albumin ratio (CAR) is a significant independent prognostic factor for advanced gastric cancer patients receiving combination immunotherapy and chemotherapy, with lower CAR levels associated with improved progression-free survival, overall survival, and higher objective response and disease control rates. By in