Letter to the Editor: Preoperative-pathologic discordance as a structural weakness in early gastric cancer management

doi:10.4251/wjgo.v18.i6.117170

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Jun 15, 2026; 18(6): 117170
Published online Jun 15, 2026. doi: 10.4251/wjgo.v18.i6.117170

Letter to the Editor: Preoperative-pathologic discordance as a structural weakness in early gastric cancer management

Hai-Fu Huang, Jing-Qi Zeng

Hai-Fu Huang, Department of Oncology, Guangzhou University of Chinese Medicine - Shenzhen Hospital, Shenzhen 518034, Guangdong Province, China

Jing-Qi Zeng, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Beijing 102488, China

Author contributions: Huang HF contributed to the literature review and drafting of the manuscript; Zeng JQ conceptualized the study, supervised the project, and critically revised the manuscript.

Supported by the Special Fund for Basic Research of Shenzhen City (2025) - Natural Science Foundation Program Project, No. JCYJ20250604190104007; and 2025 Scientific Research Project of the Health System in Futian District, Shenzhen, No. FTWS2025107.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Corresponding author: Jing-Qi Zeng, School of Chinese Materia Medica, Beijing University of Chinese Medicine, Yangguang South Street, Liangxiang Higher Education Park, Fangshan District, Beijing 102488, China. zjingqi@163.com

Received: December 1, 2025
Revised: January 10, 2026
Accepted: January 19, 2026
Published online: June 15, 2026
Processing time: 191 Days and 8 Hours

Core Tip

Core Tip: Preoperative-pathologic discordance is a common and clinically important issue in early gastric cancer management. Clinicians should recognize high-risk features early and escalate diagnostic evaluation when appropriate to preserve organ-sparing treatment options. The use of enhanced diagnostic techniques, such as targeted biopsies, virtual chromoendoscopy, and endoscopic ultrasonography, can significantly improve staging accuracy and help guide better treatment decisions, ultimately reducing unnecessary surgeries.