Wu KL, Guo D, Yang L, Li YQ, Wu YX, Zhou CF, Tang JF. Letter to the Editor: Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations. World J Gastrointest Oncol 2026; 18(6): 116624 [DOI: 10.4251/wjgo.v18.i6.116624]
Corresponding Author of This Article
Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Research Domain of This Article
Cell Biology
Article-Type of This Article
letter
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Wu KL, Guo D, Yang L, Li YQ, Wu YX, Zhou CF, Tang JF. Letter to the Editor: Bile acids in cholangiocarcinoma: Dual regulation via the hippo-yes-associated protein pathway and model limitations. World J Gastrointest Oncol 2026; 18(6): 116624 [DOI: 10.4251/wjgo.v18.i6.116624]
Kang-Li Wu, Dong Guo, Lan Yang, Yi-Qi Li, Yi-Xin Wu, School of Life and Health Sciences, Hubei University of Technology, Wuhan 430068, Hubei Province, China
Ce-Fan Zhou, Jing-Feng Tang, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China
Co-first authors: Kang-Li Wu and Dong Guo.
Author contributions: Wu KL and Guo D contributed equally as co-first authors; Wu KL wrote the original draft; Guo D and Zhou CF contributed to the conceptualization, writing, review, and editing of the manuscript; Yang L, Li YQ, and Wu YX provided some valuable opinions; all authors have reviewed and approved the final version of the manuscript.
Supported by National Key Research and Development Program of China, No. 2023YFC2507904; Innovation Group Project of Hubei Province, No. 2023AFA026; and Key Cultivation Project of Hubei Province for Science and Technology, No. 2024DJA037.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Corresponding author: Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China. cefan@hbut.edu.cn
Received: November 17, 2025 Revised: December 14, 2025 Accepted: January 22, 2026 Published online: June 15, 2026 Processing time: 205 Days and 18.2 Hours
Core Tip
Core Tip: Bile acids play a crucial regulatory role in the development and progression of cholangiocarcinoma through the hippo-yes-associated protein signaling pathway. In this study, we aim to evaluate the current significance and limitations of bile acids in cholangiocarcinoma via the hippo-yes-associated protein signaling pathway. Based on this assessment, we propose that future research should incorporate more diverse model systems to validate existing findings and further explore the interactions between this pathway and other signaling networks, thereby constructing a more comprehensive molecular mechanism landscape. This letter is intended to provide a theoretical reference for subsequent mechanistic investigations and clinical translational research, while also outlining potential future research directions in this field.
