Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.
World J Gastrointest Oncol. May 15, 2026; 18(5): 119610
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.119610
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.119610
Diagnostic and prognostic values of pancreatic juice carbohydrate antigen 19-9 and carcinoembryonic antigen levels in patients with pancreatic cancer
Bojan Trogrlić, Borna Kovačić, Dejan Hil, Ivan Šerić, Veronika Šikić, Department of Abdominal Surgery, University Hospital Centre Osijek, Osijek 31000, Croatia
Bojan Trogrlić, Zrinka Požgain, Borna Kovačić, Dejan Hil, Veronika Šikić, Faculty of Medicine, J.J. Strossmayer University Osijek, Osijek 31000, Croatia
Zrinka Požgain, Department of Abdominal Surgery, University Hospital Centre, Osijek 31000, Croatia
Goran Augustin, Department of Surgery, University Hospital Centre Zagreb, Zagreb 10000, Croatia
Author contributions: Trogrlić B and Kovačić B designed the research; Trogrlić B, Požgain Z, and Hil D performed the research; Augustin G, Hil D, and Šerić I analyzed the data; Trogrlić B, Augustin G, Požgain Z, and Šikić V wrote the paper. All authors have read and approved the final manuscript.
Institutional review board statement: The study followed the principles of the Declaration of Helsinki. It received approval from the Ethics Committee of University Hospital Centre Osijek in Osijek, Croatia (No. R2:17233-5/2017).
Informed consent statement: All participants signed the informed consent before the intervention.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No additional data are available.
Corresponding author: Goran Augustin, MD, PhD, Consultant Physician-Scientist, Staff Physician, Surgeon, Department of Surgery, University Hospital Centre Zagreb, Kišpatićeva 12, Zagreb 10000, Croatia. augustin.goran@gmail.com
Received: February 3, 2026
Revised: February 7, 2026
Accepted: February 26, 2026
Published online: May 15, 2026
Processing time: 102 Days and 13.4 Hours
Revised: February 7, 2026
Accepted: February 26, 2026
Published online: May 15, 2026
Processing time: 102 Days and 13.4 Hours
Core Tip
Core Tip: Early detection and personalized treatment are crucial for managing pancreatic cancer. Carbohydrate antigen 19-9 (CA 19-9) and carcinoembryonic antigen (CEA) help diagnose and predict metastases and recurrence. Pancreatic juice (PJ) contains tumor-specific proteins released by pancreatic cancer cells and can be collected during surgical resection or en