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World J Gastrointest Oncol. May 15, 2026; 18(5): 118849
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.118849
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.118849
FNDC5 enhances quercetin-induced anoikis in pancreatic adenocarcinoma cells via focal adhesion kinase-dependent mechanisms
Hui-Feng Gao, Ke Zhang, Chien-Shan Cheng, Ye-Hua Shen, Hao Chen, Department of Integrative Oncology, Fudan University Shanghai Cancer Center, Shanghai 200032, China
Hui-Feng Gao, Ke Zhang, Chien-Shan Cheng, Ye-Hua Shen, Hao Chen, Department of Oncology, Shanghai Medical College, Fudan University, Shanghai 200032, China
Co-corresponding authors: Ye-Hua Shen and Hao Chen.
Author contributions: Gao HF and Zhang K designed the study; Cheng CS and Shen YH performed the experiments; Shen YH and Chen H served as co-corresponding authors and jointly analyzed the data and edited the manuscript; all authors contributed to editorial changes in the manuscript, read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 82074204.
Institutional animal care and use committee statement: All experimental protocols in this study were carried out exclusively with cell lines, and therefore no experiments involving animal subjects were required.
Conflict-of-interest statement: The authors declare that they have no competing interests.
Data sharing statement: No additional data are available.
Corresponding author: Hao Chen, MD, Chief Physician, Department of Integrative Oncology, Fudan University Shanghai Cancer Center, No. 270 Dong’an Road, Shanghai 200032, China. chengkll@sina.com
Received: January 27, 2026
Revised: February 26, 2026
Accepted: March 23, 2026
Published online: May 15, 2026
Processing time: 106 Days and 17 Hours
Revised: February 26, 2026
Accepted: March 23, 2026
Published online: May 15, 2026
Processing time: 106 Days and 17 Hours
Core Tip
Core Tip: This study highlights that FNDC5 enhances quercetin-mediated growth inhibition, apoptosis, and anoikis through focal adhesion kinase/phosphatidylinositol 3-kinase/protein kinase B inhibition and mitochondrial apoptosis initiation. Our results provide further insight into the effect of irisin on pancreatic ductal adenocarcinoma (PAAD) cells and suggest a new strategy for PAAD treatment that combines quercetin and irisin.