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World J Gastrointest Oncol. May 15, 2026; 18(5): 117990
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117990
Published online May 15, 2026. doi: 10.4251/wjgo.v18.i5.117990
From bile acids to yes-associated protein: A bidirectional switch for cholangiocarcinoma therapy
Shu-Yuan Zhang, Hui Yu, Department of Geriatrics, The Fifth Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Yin Mi, Department of Radiation Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Fan-Kai Xiao, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Co-corresponding authors: Hui Yu and Fan-Kai Xiao.
Author contributions: Xiao FK and Yu H designed the research and are co-corresponding authors of this manuscript; Zhang SY and Mi Y performed the literature search and drafted the manuscript; all authors have read and approved the final manuscript.
AI contribution statement: Declaration of using generative AI and AI-assisted technologies during the writing process. The AI tool used to assist with the language editing of this manuscript is Gemini [Google Deep Blue (USA)]. During the preparation of this manuscript, this tool was only used to assist with language editing. All the outputs generated by this tool have been carefully reviewed, edited and verified by the author. All original content, interpretations and final revisions are solely the responsibility of the author.
Supported by Youth Foundation of Henan Scientific Committee, No. 202300410416; and Henan Province Medical Science, Technology Breakthrough Plan Project, No. LHGJ20190033.
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Corresponding author: Fan-Kai Xiao, MD, Doctor, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No. 1 Jianshe Road, Zhengzhou 450052, Henan Province, China. xfkw@hotmail.com
Received: December 22, 2025
Revised: January 16, 2026
Accepted: March 2, 2026
Published online: May 15, 2026
Processing time: 145 Days and 6.4 Hours
Revised: January 16, 2026
Accepted: March 2, 2026
Published online: May 15, 2026
Processing time: 145 Days and 6.4 Hours
Core Tip
Core Tip: Bile acids (BAs) exert complex, structure-dependent regulatory effects on the Hippo-yes-associated protein pathway in gastrointestinal malignancies. These editorial highlights a pivotal “bidirectional switch” mechanism where glycochenodeoxycholic acid and deoxycholic acid induce opposing outcomes in cholangiocarcinoma. By integrating the physicochemical distinctions between conjugated and unconjugated BAs with their dynamic interplay in gut microbiota dysbiosis, we propose a multidimensional “microbiota-BA-Hippo” regulatory network. Targeting this axis offers novel precision therapeutic strategies for managing cholangiocarcinoma and metabolic disorders.