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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2026; 18(2): 115689
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115689
Published online Feb 15, 2026. doi: 10.4251/wjgo.v18.i2.115689
Increasing expression of presenilin 1, β-catenin, and p-PTEN and its regulatory roles on cell invasion in gastric cancer
Xi Lin, Guo-Feng Lin, Fei-Teng Gu, Yong-Liang Li, Department of Gastrointestinal Surgery, Affiliated Hospital of Putian University, Putian 351100, Fujian Province, China
Author contributions: Lin X, Lin GF, and Gu FT contributed to this paper; Li YL designed the overall concept and made critical revisions related to important intellectual content of the manuscript; Lin X contributed to the manuscript writing and editing; All authors read and approved the final manuscript.
Supported by Science and Technology Project of Putian, No. 2022S3F006.
Institutional review board statement: This study was approved by the Ethics Committee of the Affiliated Hospital of Putian University, No. 202281.
Institutional animal care and use committee statement: This study was reviewed and approved by the Institutional Animal Care and Use Committee of the Affiliated Hospital of Putian University, No. 2022107.
Conflict-of-interest statement: All authors report no relevant conflicts of interest for this article.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: The data related to this paper can be obtained from the author on reasonable grounds.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yong-Liang Li, Director, Department of Gastrointestinal Surgery, Affiliated Hospital of Putian University, No. 999 Dongzhen East Road, Licheng District, Putian 351100, Fujian Province, China. lx05942022@163.com
Received: October 24, 2025
Revised: November 26, 2025
Accepted: December 22, 2025
Published online: February 15, 2026
Processing time: 101 Days and 19.1 Hours
Revised: November 26, 2025
Accepted: December 22, 2025
Published online: February 15, 2026
Processing time: 101 Days and 19.1 Hours
Core Tip
Core Tip: The high expression of presenilin 1 was correlated with advanced tumor stages, and its expression was positively correlated with expression of β-catenin and phosphorylation of tensin homolog deleted on chromosome ten in patients with gastric cancer (GC). The regulation of phosphatase and tensin homolog deleted on chromosome ten phosphorylation and cytoplasmic localization by presenilin 1 through β-catenin as a novel signaling pathway of GC progression could contribute to GC tumorigenesis.