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Fan XJ, Wang FS, Yao Y, Xu S, Chen CQ, Zhao ZX. Chromatin assembly factor 1 subunit B expression correlates with favorable prognosis and potential therapeutic response prediction in left-sided colorectal cancer. World J Gastrointest Oncol 2026; 18(12): 125841 [DOI: 10.4251/wjgo.125841]
World J Gastrointest Oncol. Dec 15, 2026; 18(12): 125841 Published online Dec 15, 2026. doi: 10.4251/wjgo.125841
Chromatin assembly factor 1 subunit B expression correlates with favorable prognosis and potential therapeutic response prediction in left-sided colorectal cancer
Xi-Jie Fan, Fu-Sheng Wang, Yuan Yao, Shun Xu, Chao-Qian Chen, Zong-Xian Zhao, Department of Anorectal Surgery, Fuyang City People’s Hospital, Fuyang 236000, Anhui Province, China
Author contributions: Fan XJ and Zhao ZX designed the research and completed the manuscript; Wang FS, Yao Y, Xu S, and Chen CQ performed the research; and all authors have read and approved the final version to be published.
AI contribution statement: Portions of this manuscript were edited using AI tools solely for language refinement. The authors carefully reviewed and verified all AI-assisted outputs and take full responsibility for the scientific content of the manuscript.
Supported by Fuyang Municipal Science and Technology Bureau, Anhui, China, No. FK20245505; Anhui Provincial Health Commission, No. AHWJ2023Baa20164; and Bengbu Medical University, No. 2022byzd168.
Institutional review board statement: This study was approved by the Medical Ethics Committee of Fuyang People’s Hospital, approval No.[2023]42.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The data generated or analyzed in this study are available from the corresponding author.
Corresponding author: Zong-Xian Zhao, MD, Department of Anorectal Surgery, Fuyang City People’s Hospital, No. 501 Sanqing Road, Yingzhou District, Fuyang 236000, Anhui Province, China. 461901580@qq.com
Received: July 20, 2026 Revised: August 22, 2026 Accepted: October 29, 2026 Published online: December 15, 2026 Processing time: 115 Days and 10.9 Hours
Core Tip
Core Tip: Accumulating evidence supports the notion that left-sided colorectal cancer (CRC) and right-sided CRC represent distinct disease entities. Precise molecular subtyping of CRC is therefore an urgent unmet need to enable individualized precision treatment. Currently, the biological function of chromatin assembly factor 1 subunit B (CHAF1B) in CRC remains largely uncharacterized. In this study, elevated CHAF1B was an independent favorable prognostic biomarker for left-side CRC patients and correlated with enhanced cellular sensitivity to first-line chemotherapeutic agents. High CHAF1B expression was significantly associated with microsatellite instability-high status and high tumor mutational burden, as well as potential favorable therapeutic outcomes in patients receiving immunotherapy.
