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World J Gastrointest Oncol. Dec 15, 2026; 18(12): 124885
Published online Dec 15, 2026. doi: 10.4251/wjgo.124885
Published online Dec 15, 2026. doi: 10.4251/wjgo.124885
Dynamic gut microbiota and serum metabolite changes post-gastrectomy affect nutrient absorption in gastric cancer patients
Min-Xia Li, Department of Clinical Laboratory, Danyang People’s Hospital, Danyang 212300, Jiangsu Province, China
Hui-Chun Chen, Department of General Surgery, The Third Affiliated Hospital of Wenzhou Medical University, Rui’an 325200, Zhejiang Province, China
Lei-Lei Yu, Pei-Sheng Jin, Department of Gastroenterology, Ruian People’s Hospital, Rui’an 325200, Zhejiang Province, China
Author contributions: Li MX, Chen HC, and Yu LL performed the research; Jin PS designed the research study; all authors contributed to the writing and revision of the manuscript and approved the final version.
AI contribution statement: ChatGPT and DeepSeek were used as editorial aids for language polishing and formatting assistance. All AI-assisted content was critically reviewed and revised by the authors, who take full responsibility for the accuracy, originality, and integrity of the manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of the Danyang People’s Hospital, approval No. 20260615.
Informed consent statement: All research participants or their legal guardians provided written informed consent prior to study registration.
Conflict-of-interest statement: The authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: No other data available.
Corresponding author: Pei-Sheng Jin, Chief Physician, Department of Gastroenterology, Ruian People’s Hospital, No. 108 Wansong Road, Rui’an 325200, Zhejiang Province, China.
Received: July 10, 2026
Revised: August 4, 2026
Accepted: September 15, 2026
Published online: December 15, 2026
Processing time: 122 Days and 3.9 Hours
Revised: August 4, 2026
Accepted: September 15, 2026
Published online: December 15, 2026
Processing time: 122 Days and 3.9 Hours
Core Tip
Core Tip: This prospective longitudinal study compared the dynamic effects of distal gastrectomy, total gastrectomy, and endoscopic submucosal dissection on gut microbiota and serum metabolites in gastric cancer patients. A surgery-extent-dependent gradient of dysbiosis and bile acid metabolic disturbances was observed. Endoscopic submucosal dissection preserved gastric integrity, thereby maintaining microbial homeostasis. Early postoperative Streptococcus overgrowth may serve as an early warning sign of long-term malnutrition.