Weiwikang Formula ameliorates precancerous lesions of gastric cancer: Associations with the HIF-1α/BNIP3 axis, mitophagy, and glycolysis
Xin-Fang Zhang, Guan-Hua Lv, Cheng-Hui Zhu, Shu-Jian An, Xi-Ran Yang
Xin-Fang Zhang, Shu-Jian An, Xi-Ran Yang, Graduate School, Liaoning University of Traditional Chinese Medicine, Shenyang 110847, Liaoning Province, China
Guan-Hua Lv, Cheng-Hui Zhu, Department of Gastroenterology and Hepatology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Provincial Institute of Traditional Chinese Medicine, Shenyang 110031, Liaoning Province, China
Co-corresponding authors: Guan-Hua Lv and Cheng-Hui Zhu.
Author contributions: Zhang XF performed the experiments, analyzed the data, and wrote the original draft of the manuscript; Lv GH and Zhu CH conceived and designed the study, supervised the project, and critically revised the manuscript as co-corresponding authors; An SJ and Yang XR contributed to the animal experiments and sample collection; all authors have read and approved the final version of the manuscript.
AI contribution statement: The authors take full responsibility and accountability for all content of this manuscript, including any portions for which AI tools were used as assistive technologies. All AI-assisted outputs were carefully reviewed, validated, and approved by the authors. AI tools were not used to generate original scientific data, perform independent scientific analyses, or draw scientific conclusions.
Supported by the Joint Program of the Science and Technology Plan of Liaoning Province (Natural Science Foundation - General Program), No. 2024012225-JH4/4800.
Institutional animal care and use committee statement: All animal procedures were reviewed and approved by the Institutional Animal Care and Use Committee of Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine (approval No. LZYY250203).
Conflict-of-interest statement: The authors declare no conflict of interest in publishing the manuscript.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Data sharing statement: No additional data are available.
Corresponding author: Guan-Hua Lv, PhD, Director, Full Professor, Department of Gastro
enterology and Hepatology, Second Affiliated Hospital of Liaoning University of Traditional Chinese Medicine, Liaoning Provincial Institute of Traditional Chinese Medicine, No. 60 Huanghebei Street, Huanggu District, Shenyang 110031, Liaoning Province, China.
809007025@qq.com
Received: June 23, 2026
Revised: July 29, 2026
Accepted: September 18, 2026
Published online: December 15, 2026
Processing time: 140 Days and 3.8 Hours
