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World J Gastrointest Oncol. Dec 15, 2026; 18(12): 124250
Published online Dec 15, 2026. doi: 10.4251/wjgo.124250
Published online Dec 15, 2026. doi: 10.4251/wjgo.124250
Preoperative cancer-inflammation-prognostic-index-based nomogram for overall survival in stage I-III gastric cancer
Ning Chang, Zhi-Jian Wei, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China
Li-Xiang Zhang, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China
En-Ze Zhou, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230032, Anhui Province, China
A-Man Xu, Department of Gastrointestinal and Hernia Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230022, Anhui Province, China
Co-first authors: Ning Chang and Li-Xiang Zhang.
Co-corresponding authors: Zhi-Jian Wei and A-Man Xu.
Author contributions: Chang N and Zhang LX conceptualized and designed the study, drafted the initial manuscript and collected and analysed the data, they contributed equally to this article, they are the co-first authors of this manuscript; Zhou EZ provided software support and prepared the figures and tables; Wei ZJ and Xu AM reviewed and revised the manuscript they contributed equally to this article, they are the co-corresponding authors of this manuscript; and all authors read and approved the final manuscript.
AI contribution statement: During the preparation of this manuscript, the authors used ChatGPT (OpenAI) solely to improve language clarity and readability. The authors subsequently reviewed and edited all AI-assisted content and take full responsibility for the final manuscript.
Institutional review board statement: This study was approved by the Medical Ethics Committee of The First Affiliated Hospital of Anhui Medical University, approval No. PJ 2025-01-61.
Informed consent statement: Patients were not required to give informed consent to the study because the analysis used anonymous clinical data that was obtained after each patient agreed to treatment by written consent.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: The anonymized data and statistical code supporting the findings of this study are available from the corresponding author upon reasonable request.
Corresponding author: Zhi-Jian Wei, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, No. 218 Jixi Road, Hefei 230031, Anhui Province, China. yfy1041018@fy.ahmu.edu.cn
Received: June 10, 2026
Revised: July 30, 2026
Accepted: September 15, 2026
Published online: December 15, 2026
Processing time: 153 Days and 2.7 Hours
Revised: July 30, 2026
Accepted: September 15, 2026
Published online: December 15, 2026
Processing time: 153 Days and 2.7 Hours
Core Tip
Core Tip: The Cancer Inflammation Prognostic Index (CIPI), calculated as carcinoembryonic antigen multiplied by the neutrophil-to-lymphocyte ratio, integrates tumour burden with systemic inflammation. In this retrospective cohort of 1071 patients with stage I-III gastric cancer undergoing radical gastrectomy, a high preoperative CIPI was independently associated with poorer overall survival and further stratified risk within tumour-node-metastasis stages. A CIPI-based nomogram showed modestly better discrimination than a reference T-N model and acceptable calibration on internal validation. CIPI may complement conventional staging, but external validation and prospective assessment are required before clinical implementation.