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World J Gastrointest Oncol. Dec 15, 2026; 18(12): 124081
Published online Dec 15, 2026. doi: 10.4251/wjgo.124081
Published online Dec 15, 2026. doi: 10.4251/wjgo.124081
Development and validation of a computed tomography-based radiomics nomogram for predicting metachronous liver metastasis in colorectal cancer
Yang Li, Mi Wang, Tian Tian, Wei-Guo Zhang, Zhi-Hua Lu, Department of Radiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, Suzhou 215123, Jiangsu Province, China
Zi-Cheng Zhou, Suzhou Medical College of Soochow University, Suzhou 215123, Jiangsu Province, China
Heng Jiang, Department of Radiology, Changshu No. 1 People’s Hospital, Affiliated Changshu Hospital of Soochow University, Changshu 215500, Jiangsu Province, China
Xi-Ming Wang, Department of Radiology, The First Affiliated Hospital of Soochow University, Suzhou 215031, Jiangsu Province, China
Co-first authors: Yang Li and Zi-Cheng Zhou.
Co-corresponding authors: Wei-Guo Zhang and Zhi-Hua Lu.
Author contributions: Li Y, Zhou ZC, and Jiang H had full access to all of the data in the study and take responsibility for the integrity of the data and the accuracy of the data analysis; Li Y and Lu ZH were involved in the study concepts and design; all authors involved in the acquisition, analysis and interpretation of data; Wang XM and Zhang WG supervised the analysis; Li Y and Lu ZH involved in the draft of the manuscript; Li Y and Zhou ZC contributed equally to this study as co-first authors; Zhang WG and Lu ZH contributed equally as co-corresponding authors. All authors read, critically revised and approved the manuscript.
AI contribution statement: No AI tools were used in this study.
Supported by Suzhou Clinical Special Disease Diagnosis and Treatment Program, No. LCZX202346; and Junzheng Fund of Soochow University.
Institutional review board statement: The study protocol was approved by the Ethics Committee of The Fourth Affiliated Hospital of Soochow University, No. 251315.
Informed consent statement: The requirement for written informed consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
STROBE statement: The authors have read the STROBE Statement-checklist of items, and the manuscript was prepared and revised according to the STROBE Statement-checklist of items.
Data sharing statement: The data supporting the findings of this study are available from the authors upon reasonable request.
Corresponding author: Zhi-Hua Lu, MD, Department of Radiology, The Fourth Affiliated Hospital of Soochow University, Suzhou Dushu Lake Hospital, Medical Center of Soochow University, No. 9 Chongwen Road, Suzhou Industrial Park, Suzhou 215123, Jiangsu Province, China. luzhihua4100@suda.edu.cn
Received: June 8, 2026
Revised: July 27, 2026
Accepted: September 9, 2026
Published online: December 15, 2026
Processing time: 157 Days and 8.3 Hours
Revised: July 27, 2026
Accepted: September 9, 2026
Published online: December 15, 2026
Processing time: 157 Days and 8.3 Hours
Core Tip
Core Tip: This study is the first to integrate intra- and peritumoral radiomics features to predict colorectal cancer-related metachronous liver metastasis, outperforming single-region radiomics models. The established nomogram provides a novel non-invasive tool for liver metastasis-free survival prognostic evaluation and individualised clinical risk management.