Letter to the Editor: Serum chitinase-3-like protein 1 as a biomarker in liver disease: Concerns regarding postoperative recurrence and hepatitis-related confounding

doi:10.4251/wjgo.124077

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 18, Issue 11

This Article

(3)

(0)

(2)

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

- Full Article (XML)

Correspondence

Copyright: ©Author(s) 2026. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution-NonCommercial (CC BY-NC 4.0) license. No commercial re-use. See permissions. Published by Baishideng Publishing Group Inc.

World J Gastrointest Oncol. Nov 15, 2026; 18(11): 124077
Published online Nov 15, 2026. doi: 10.4251/wjgo.124077

Letter to the Editor: Serum chitinase-3-like protein 1 as a biomarker in liver disease: Concerns regarding postoperative recurrence and hepatitis-related confounding

Chang-Zhi Chen, Lin Li, Jing-Feng Qiu

Chang-Zhi Chen, Lin Li, Jing-Feng Qiu, Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital of Guang Xi Medical University, Nanning 530031, Guangxi Zhuang Autonomous Region, China

Author contributions: Chen CZ and Li L reviewed the literature and drafted the manuscript; Qiu JF conceived and supervised the work and critically revised the manuscript; all authors read and approved the final manuscript.

AI contribution statement: The authors declare that no AI tools were used in the development or writing of this manuscript and take full responsibility for its integrity, accuracy, and originality.

Conflict-of-interest statement: The author(s) report no conflicts of interest in this work.

Corresponding author: Chang-Zhi Chen, Department of Hepatobiliary and Pancreatic Surgery, The Third Affiliated Hospital of Guang Xi Medical University, No. 13 Dancun Road, Nanning 530031, Guangxi Zhuang Autonomous Region, China. chenchangzhi1@163.com

Received: June 5, 2026
Revised: July 21, 2026
Accepted: September 23, 2026
Published online: November 15, 2026
Processing time: 142 Days and 1.5 Hours

Core Tip

Core Tip: Serum chitinase-3-like protein 1 (CHI3L1) is a promising biomarker for liver fibrosis, cirrhosis, hepatocellular carcinoma, and postoperative recurrence. However, its value for recurrence surveillance would be better supported by comparing postoperative CHI3L1 levels between patients with and without recurrence after curative resection. In addition, underlying hepatitis and inflammatory activity may influence serum CHI3L1 levels and confound diagnostic performance. These factors should be considered when interpreting the clinical utility of CHI3L1 in liver disease.