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©The Author(s) 2026. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2026; 18(1): 114924
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114924
Published online Jan 15, 2026. doi: 10.4251/wjgo.v18.i1.114924
Solid dispersion of BIBR1532: A potent therapeutic for oesophageal squamous cancer
Xue-Juan Zhang, Nai-Xuan Deng, Huan-Qing Zhang, Jie-Zuan Cen, Zi-Xuan Zheng, Meng-Qin Guo, Zheng-Wei Huang, College of Pharmacy, Jinan University, Guangzhou 511443, Guangdong Province, China
Author contributions: Zhang XJ contributed to manuscript writing and file sorting; Deng NX contributed to core tip and conclusion writing; Zhang HQ contributed to abstract writing and Figure 1 making; Cen JZ contributed to introduction writing and Figures 2 and 3 making; Zheng ZX contributed to reference list inserting; Guo MQ revised and polished the manuscript; Huang ZW contributed to theoretical framework, supervision, proofreading, and submission; all of the authors read and approved the final version of the manuscript to be published.
Supported by “Continuation” Project of Excellent Doctors, Guangdong Basic and Applied Basic Research Foundation, No. 2025A04J5082; and Guangdong Basic and Applied Basic Research Foundation, No. 2024A1515011236.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zheng-Wei Huang, PhD, Associate Professor, College of Pharmacy, Jinan University, No. 855 East Xingye Dadao, Panyu District, Guangzhou 511443, Guangdong Province, China. huangzhengw@jnu.edu.cn
Received: October 10, 2025
Revised: November 5, 2025
Accepted: November 20, 2025
Published online: January 15, 2026
Processing time: 102 Days and 0.7 Hours
Revised: November 5, 2025
Accepted: November 20, 2025
Published online: January 15, 2026
Processing time: 102 Days and 0.7 Hours
Core Tip
Core Tip: To overcome the poor aqueous solubility and low druggability of the anti-cancer agent BIBR1532, we proposed hydroxypropyl methylcellulose (HPMC)-based solid dispersion technology for solubilisation. This approach has lower costs and risks than lipid-based formulations for large-scale manufacturing. We selected an HPMC-based strategy because of its low hygroscopicity and high glass transition temperature. These properties ensure the release and absorption of the drug in the upper gastrointestinal tract, which is a key requirement for the treatment of esophageal squamous cell carcinoma.