Retrospective Study
Copyright ©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2025; 17(8): 109245
Published online Aug 15, 2025. doi: 10.4251/wjgo.v17.i8.109245
Gallbladder and biliary tract cancer burden trends in Brazil, Russian Federation, India, China, and South Africa in 1990-2021
Yun-Long Cui, Xu Bao, Dong-Ming Liu, Han Mu, Ge Yu
Yun-Long Cui, Xu Bao, Dong-Ming Liu, Han Mu, Ge Yu, Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute and Hospital, Tianjin 300060, China
Author contributions: Cui YL, Bao X, Liu DM, Mu H and Yu G contributed to the study conception and design; Cui YL designed the research and reviewed the manuscript; Liu DM, Bao X, Mu H and Yu G wrote the manuscript; all authors have read and approved the manuscript.
Supported by the Key Project of Science & Technology Development Fund of Tianjin Education Commission for Higher Education, No. 2024ZD023.
Institutional review board statement: This is a retrospective study utilizing public databases. It does not involve patient ethics or animal ethics considerations. As a retrospective analysis based on publicly available databases, this study requires neither.
Informed consent statement: As this retrospective study utilized de-identified, publicly available datasets, no signed informed consent forms or related documentation were required or obtained.
Conflict-of-interest statement: The authors declare no conflict of interest.
Data sharing statement: No data applicable.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yun-Long Cui, Professor, Department of Hepatobiliary Cancer, Tianjin Medical University Cancer Institute and Hospital, Tiyuanbei, Huanhuxi Road, Tianjin 300060, China. jinhpj@163.com
Received: May 7, 2025
Revised: May 30, 2025
Accepted: July 14, 2025
Published online: August 15, 2025
Processing time: 101 Days and 21.3 Hours
Core Tip

Core Tip: The global burden of gallbladder and biliary tract cancer (GBTC) continues to rise, with marked heterogeneity across Brazil, Russian Federation, India, China, and South Africa (BRICS) nations. Using global burden of disease 2021 data, age-period-cohort modeling revealed a 101% increase in global GBTC incidence and 74% mortality growth from 1990-2021. Declining age-standardized mortality rates were observed in Brazil, Russia, and China, contrasting with increases in India and South Africa. Male predominance in China vs female predominance in other BRICS countries was noted. Trend analysis highlighted China's unique initial decline followed by a rebound in incidence, underscoring the urgent need for targeted prevention strategies.