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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Mar 15, 2025; 17(3): 98703
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98703
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.98703
DNMT1 promotes the proliferation and migration of gastric cancer cells by inducing microRNA-125a-5p methylation to promote SERPINE1 protein
Hui Xie, Ru-Hong Li, Yue-Wen Zhang, Ao-Ran Guan, Department of General Surgery, Yan’an Hospital of Kunming City, Kunming 650051, Yunnan Province, China
Hui Wang, Xi-Rui Fan, Xiao-Xue He, Department of Digestive Internal Medicine, Yan’an Hospital of Kunming City, Kunming 650051, Yunnan Province, China
Co-first authors: Hui Xie and Hui Wang.
Author contributions: Xie H and Wang H contributed equally to this work; Wang H contributed to visualization; Xie H contributed to validation; Xie H and Wang H contributed to conceptualization, project administration, writing original draft; Guan AR contributed to funding acquisition, investigation, resources, supervision, writing review and editing; Fan XR and He XX contributed to data curation and software; Li RH, Zhang YW contributed to formal analysis, and methodology; All authors have read and approved the final manuscript.
Supported by the Research Program of the Science and Technology Department of Yunnan Province, No. 202101AY070001-204.
Institutional review board statement: This study was conducted in accordance with the Declaration of Helsinki (as revised in 2013) and was approved by the Ethics Committee of Yan’an Hospital of Kunming City/Yan’an Hospital Affiliated to Kunming Medical University (No. 2020-078-01).
Conflict-of-interest statement: The authors declare that they have no conflict of interest.
Data sharing statement: No additional data are available.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ao-Ran Guan, Department of General Surgery, Yan’an Hospital of Kunming City, No. 245 Renmin East Road, Kunming 650051, Yunnan Province, China.
Received: July 4, 2024
Revised: December 11, 2024
Accepted: December 23, 2024
Published online: March 15, 2025
Processing time: 225 Days and 7.7 Hours
Revised: December 11, 2024
Accepted: December 23, 2024
Published online: March 15, 2025
Processing time: 225 Days and 7.7 Hours
Core Tip
Core Tip: This study revealed the tumor suppressive effect of microRNAs (miR)-125a-5p in gastric cancer (GC) through inhibition of cell proliferation, migration and invasion, and regulation of epithelial-mesenchymal transition related protein expression. The low expression of miR-125a-5p is associated with DNMT1-mediated promoter methylation and is negatively correlated with SERPINE1 expression. This discovery provides a new target for GC therapy.