Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis

doi:10.4251/wjgo.v17.i3.102434

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World Journal of Gastrointestinal Oncology

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1948-5204

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Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

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World J Gastrointest Oncol. Mar 15, 2025; 17(3): 102434
Published online Mar 15, 2025. doi: 10.4251/wjgo.v17.i3.102434

Expression significance of biomarker MORC4 in colorectal cancer patients and its relationship with pathological features and prognosis

Li Wei, Liang Wang, Ya-Gang Liu, Li-Fei Gao

Li Wei, Liang Wang, Ya-Gang Liu, Department of General Surgery, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China

Li-Fei Gao, Department of Hepatobiliary and Pancreatic Surgery, Cangzhou Central Hospital, Cangzhou 061000, Hebei Province, China

Author contributions: Wang L designed the research study; Wei L performed the research; Liu YG and Gao LF conducted experiments, analyzed the data; and all authors contributed to editorial changes in the manuscript. All authors read and approved the final manuscript.

Institutional review board statement: This study was approved by the Ethics Committee of Cangzhou Central Hospital, No. 29795793.

Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.

Data sharing statement: No additional data are available.

Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Li-Fei Gao, PhD, Associate Chief Physician, Department of Hepatobiliary and Pancreatic Surgery, Cangzhou Central Hospital, No. 16 Xinhua West Road, Yunhe District, Cangzhou 061000, Hebei Province, China. gaolumu3859@163.com

Received: November 7, 2024
Revised: December 8, 2024
Accepted: January 10, 2025
Published online: March 15, 2025
Processing time: 99 Days and 3.5 Hours

Core Tip

Core Tip: To investigate the expression significance of the chromatin-remodeling protein MORC family CW-type zinc finger 4 as a biomarker in colorectal cancer patients, and to explore its relationship with pathological features and prognosis. The upregulation of MORC family CW-type zinc finger 4 expression in colorectal cancer patients is closely related to disease severity and prognosis, suggesting its potential as an evaluation biomarker, which warrants further investigation.