Resveratrol and pancreatic cancers: Questions and future perspectives

Core Tip

Core Tip: A promising new direction for the treatment of pancreatic cancer has been investigated and reported by Jiang et al. Using immunohistochemistry, the authors assessed pancreatic cancer tissues and detected the presence of senescent cancer-associated fibroblasts (CAFs) in the tumor microenvironment. Following this, the authors observed the ability of the natural polyphenolic compound resveratrol to reverse the senescent CAF phenotype and inhibit pancreatic cancer progression in vitro and in vivo. This editorial assesses important aspects of the original article and discusses future perspectives of resveratrol-containing therapy.