Protein tyrosine phosphatase nonreceptor 2: A New biomarker for digestive tract cancers

doi:10.4251/wjgo.v17.i2.100546

Advanced Search

BPG is committed to discovery and dissemination of knowledge

Home / Archive / Volume 17, Issue 2

This Article

Peer-Review Report of This Article

CrossCheck and Google Search of This Article

Academic Rules and Norms of This Article

Citation of this article

Corresponding Author of This Article

Research Domain of This Article

Article-Type of This Article

Open-Access Policy of This Article

Times Cited Counts in Google of This Article

Number of Hits and Downloads for This Article

Total Article Views (2693)

All Articles published online

The chart showing PDF series, HTML series, Figures (1-2) series, Tables (1-2) series.

Item

Count

PDF

134

HTML

1249

Figures (1-2)

349

Tables (1-2)

368

Sum=2100

Publishing Process of This Article

The chart showing Browse series, Download series.

Item

Count

Browse

Download

389

Sum=472

Feb 15, 2025 (publication date) through Mar 2, 2026

Times Cited of This Article

Times Cited (0)

Journal Information of This Article

Publication Name

World Journal of Gastrointestinal Oncology

ISSN

1948-5204

Publisher of This Article

Baishideng Publishing Group Inc, 7041 Koll Center Parkway, Suite 160, Pleasanton, CA 94566, USA

Editorial

World J Gastrointest Oncol. Feb 15, 2025; 17(2): 100546
Published online Feb 15, 2025. doi: 10.4251/wjgo.v17.i2.100546

Protein tyrosine phosphatase nonreceptor 2: A New biomarker for digestive tract cancers

Ozlem Ceren Gunizi, Gulsum Ozlem Elpek

Ozlem Ceren Gunizi, Gulsum Ozlem Elpek, Department of Pathology, Akdeniz University Medical School, Antalya 07070, Türkiye

Author contributions: Gunizi OC and Elpek GO were involved in data curation, designing and performing the research, and writing the paper.

Conflict-of-interest statement: The authors declare there is no conflict of interest.

Corresponding author: Gulsum Ozlem Elpek, MD, Professor, Department of Pathology, Akdeniz University Medical School, Dumlupinar Bulvarı, Antalya 07070, Türkiye. elpek@akdeniz.edu.tr

Received: August 19, 2024
Revised: November 2, 2024
Accepted: November 20, 2024
Published online: February 15, 2025
Processing time: 151 Days and 20.5 Hours

Core Tip

Core Tip: Protein tyrosine phosphatase nonreceptor 2 (PTPN2) is a member of the protein tyrosine phosphatase family of signaling proteins. Numerous studies have examined the roles of this molecule in antitumor immunity and therapy because of its significant effects on a wide range of events, including the production and distribution of immune cells and numerous pathways that are important to the behavior and treatment of cancers. The role of PTPN2 in gastrointestinal (GI) cancers has been investigated in a limited number of studies, indicating that PTPN2 has heterogeneous effects on different tumors and even on the same type of GI cancer. Currently, this situation limits the recommendation of PTPN2 as a potential biomarker for predicting cancer prognosis and the efficacy of immunotherapy necessitates further studies in GI tumors.