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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2025; 17(11): 111264
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.111264
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.111264
Precision medicine advances in pancreatic cancer driven by genomic and molecular alterations
Xiang Li, Department of First Operation Room, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Yan Jiao, Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, Changchun 130021, Jilin Province, China
Author contributions: Li X wrote the initial draft; Jiao Y contributed to the study design and literature review; Liu YH contributed to the study design, help to design the study and revisions to the final manuscript. All authors approved the final version to be published.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ya-Hui Liu, Department of Hepatobiliary and Pancreatic Surgery, General Surgery Center, The First Hospital of Jilin University, No. 1 Xinmin Street, Changchun 130021, Jilin Province, China. yahui@jlu.edu.cn
Received: June 26, 2025
Revised: July 13, 2025
Accepted: September 24, 2025
Published online: November 15, 2025
Processing time: 141 Days and 0.2 Hours
Revised: July 13, 2025
Accepted: September 24, 2025
Published online: November 15, 2025
Processing time: 141 Days and 0.2 Hours
Core Tip
Core Tip: This review highlights the transformative impact of precision medicine in pancreatic ductal adenocarcinoma by focusing on clinically relevant genomic and molecular alterations such as Kirsten rat sarcoma viral oncogene homolog and breast cancer susceptibility gene mutations, rare actionable fusions, and co-mutational signatures. It emphasizes the importance of integrating routine molecular profiling into clinical workflows to guide targeted therapies and personalized treatment strategies.