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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Nov 15, 2025; 17(11): 110468
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.110468
Published online Nov 15, 2025. doi: 10.4251/wjgo.v17.i11.110468
Emerging non-invasive imaging biomarkers of Ki-67 in pancreatic cancer: Toward predictive precision oncology
Yi-Xin Wu, Rui Tian, Xiao-Wen Li, Jie-Yu Guo, Jing-Feng Tang, Ce-Fan Zhou, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, Wuhan 430068, Hubei Province, China
Author contributions: Wu YX wrote the original draft; Zhou CF and Tang JF contributed to the conceptualization, writing, review, and editing of the manuscript; Tian R, Li XW, and Guo JY provided some valuable opinions. All authors have reviewed and approved the final version of the manuscript.
Supported by the National Key R&D Program of China, No. 2023YFC2507900; the National Natural Science Foundation of China, No. 32270768, No. 82273970, and No. 82370715; the Innovation Group Project of Hubei Province, No. 2023AFA026; the Key Cultivation Project of Hubei Province for Science and Technology, No. 2024DJA037; and the National Natural Science Foundation of Hubei, No. 2025AFA085.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ce-Fan Zhou, PhD, Professor, School of Life and Health Sciences, Institute of Biomedical Research, National “111” Center for Cellular Regulation and Molecular Pharmaceutics, Key Laboratory of Fermentation Engineering (Ministry of Education), Hubei University of Technology, No. 28 Nanli Road, Wuhan 430068, Hubei Province, China.
Received: June 10, 2025
Revised: July 5, 2025
Accepted: September 22, 2025
Published online: November 15, 2025
Processing time: 160 Days and 14.5 Hours
Revised: July 5, 2025
Accepted: September 22, 2025
Published online: November 15, 2025
Processing time: 160 Days and 14.5 Hours
Core Tip
Core Tip: Ki-67 expression levels in tumor cells function as both an early predictor of treatment response and a long-term prognostic factor in cancer patients. In this study, we begin by assessing the limitations of current non-invasive imaging techniques for evaluating Ki-67 in pancreatic cancer. Subsequently, we explore more rational methodological refinements, including prospective studies and combined imaging modalities, with the objective of enhancing predictive accuracy. This discussion also highlights potential future research directions.