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©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Oct 15, 2025; 17(10): 111339
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.111339
Published online Oct 15, 2025. doi: 10.4251/wjgo.v17.i10.111339
Revolutionizing gastrointestinal cancer research with artificial intelligence: From precision patient stratification to real-world evidence
Zhe Wang, Rui-Ying Zhang, Feng Wang, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, Henan Province, China
Cheng Ji, Department of Clinical Medicine, North Henan Medical University, Xinxiang 455000, Henan Province, China
Jia-Yi Zhang, Bing-Tong Yue, Department of Clinical Medicine, The First Clinical Medical College of Zhengzhou University, Zhengzhou 45000, Henan Province, China
Co-first authors: Zhe Wang and Rui-Ying Zhang.
Author contributions: Wang Z and Zhang RY contributed equally to this work as co-first authors; Zhang JY and Wang F conceived and supervised the study and made critical revisions; Yue BT and Ji C performed the literature search and assisted in data organization; Wang Z drafted the original manuscript; all authors contributed to manuscript preparation and approved the final version for submission.
Conflict-of-interest statement: The authors declare that they have no known competing financial interests or personal relationships that could have appeared to influence the work reported in this paper.
Open Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Feng Wang, MD, PhD, Professor, Senior Researcher, Senior Scientist, Department of Oncology, The First Affiliated Hospital of Zhengzhou University, No. 50 Eastern Jianshe Road, Zhengzhou 450052, Henan Province, China. zzuwangfeng@zzu.edu.cn
Received: July 1, 2025
Revised: July 28, 2025
Accepted: August 27, 2025
Published online: October 15, 2025
Processing time: 108 Days and 23 Hours
Revised: July 28, 2025
Accepted: August 27, 2025
Published online: October 15, 2025
Processing time: 108 Days and 23 Hours
Core Tip
Core Tip: Artificial intelligence (AI) is reshaping gastrointestinal cancer research by improving patient stratification, streamlining clinical trial design, and enabling real-world data integration. This review highlights how AI can accelerate trial timelines, enhance precision, and support remote monitoring, while also addressing key challenges in data standardization and ethical implementation.