©The Author(s) 2025. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2025; 17(1): 100199
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100199
Published online Jan 15, 2025. doi: 10.4251/wjgo.v17.i1.100199
Controversies around the treatment of peritoneal metastases of colorectal cancer
Francisco J Morera-Ocon, Francisco Landete-Molina, Department of General Surgery, Hospital General de Requena, Requena 46340, Spain
Clara Navarro-Campoy, Department of Gynecology and Obstetrics, Hospital 9 Octubre, Valencia 46015, Spain
Ticiano Guastella, Department of Pathology, Hospital General de Requena, Requena 46340, Spain
Author contributions: Morera-Ocon FJ drafted the manuscript; Morera-Ocon FJ and Navarro-Campoy C translated and completed the manuscript; Guastella T and Landete-Molina F reviewed the manuscript. All authors contributed to the manuscript revision and approved the submitted version.
Conflict-of-interest statement: The authors have nothing to disclose.
Corresponding author: Francisco J Morera-Ocon, PhD, Surgeon, Surgical Oncologist, Department of General Surgery, Hospital General de Requena, Paraje Casablanca s/n, Requena 46340, Spain. fmoreraocon@gmail.com
Received: August 9, 2024
Revised: October 24, 2024
Accepted: November 7, 2024
Published online: January 15, 2025
Processing time: 124 Days and 23.5 Hours
Revised: October 24, 2024
Accepted: November 7, 2024
Published online: January 15, 2025
Processing time: 124 Days and 23.5 Hours
Core Tip
Core Tip: Local control of peritoneal metastasis in colorectal cancer requires surgical resection to assist the outcome of systemic chemotherapy and target therapy. Despite the negative results of a randomized phase III trial studying the effect of oxaliplatin as a hyperthermic intraperitoneal chemotherapy (HIPEC) agent, HIPEC therapy may work in synergy with complete surgical resection to achieve locoregional control of the disease. Studies focusing on diagnostic tools to achieve better selection of patients who will benefit from comprehensive treatment (surgery, HIPEC, and systemic chemotherapy) are welcome.