Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

doi:10.4251/wjgo.v16.i8.3651

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World Journal of Gastrointestinal Oncology

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Basic Study

World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3651-3671
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3651

Lecithin-cholesterol acyltransferase is a potential tumor suppressor and predictive marker for hepatocellular carcinoma metastasis

Yan Li, Li-Na Jiang, Bo-Kang Zhao, Mei-Ling Li, Yi-Yun Jiang, Yi-Si Liu, Shu-Hong Liu, Li Zhu, Xin Ye, Jing-Min Zhao

Yan Li, Li-Na Jiang, Mei-Ling Li, Yi-Yun Jiang, Shu-Hong Liu, Li Zhu, Department of Pathology and Hepatology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China

Bo-Kang Zhao, Department of Hepatology, Center of Infectious Diseases and Pathogen Biology, The First Hospital of Jilin University, Changchun 130061, Jilin Province, China

Yi-Si Liu, First Department of Liver Disease Center, Beijing Youan Hospital, Capital Medical University, Beijing 100069, China

Xin Ye, Key Laboratory of Pathogenic Microbiology and Immunology, Institute of Microbiology, Chinese Academy of Sciences, Beijing 100101, China

Xin Ye, Savaid Medical School, University of Chinese Academy of Sciences, Beijing 100190, China

Jing-Min Zhao, Department of Pathology, The Fifth Medical Center of Chinese PLA General Hospital, Beijing 100039, China

Co-first authors: Yan Li and Li-Na Jiang.

Co-corresponding authors: Xin Ye and Jing-Min Zhao.

Author contributions: Li Y contributed to performing the experiments, analyzing the data, study concept and design; Jiang LN contributed to writing and revising the manuscript, study concept and design; Zhao BK contributed to collecting clinical specimens, revision and language polishing of manuscript; Li ML contributed to performing immunohistochemical experiments; Jiang YY contributed to constructing plasmids; Liu YS contributed to collecting clinical specimens; Liu SH contributed to performing pathological diagnosis; Zhu L contributed to capturing immunohistochemical images; Ye X contributed to supervising the project and performing critical revision of the manuscript; Zhao JM contributed to study concept and design, analyzing the data, financial support, supervising the project, and performing critical revision of the manuscript; and all authors discussed the results, commented on the manuscript, and read and approved the final manuscript. Li Y and Jiang LN contributed equally to this work as co-first authors; Ye X and Zhao JM contributed equally (critical revision) to this work as co-corresponding authors.

Supported by the National Natural Science Foundation of China, No. 92159305; and National Key R&D Program of China, No. 2023YFC2308104.

Institutional review board statement: The study was reviewed and approved by the Ethics Committee of Chinese PLA General Hospital.

Conflict-of-interest statement: The authors who have taken part in this study declared that they do not have anything to disclose regarding funding or conflict of interest with respect to this manuscript.

Data sharing statement: The authors confirm that the data supporting the findings of this study are available within the article and its Supplementary materials.

Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/

Corresponding author: Jing-Min Zhao, MD, Professor, Department of Pathology, The Fifth Medical Center of Chinese PLA General Hospital, No. 100 Xisihuan Middle Road, Beijing 100039, China. jmzhao302@163.com

Received: April 24, 2024
Revised: May 27, 2024
Accepted: June 18, 2024
Published online: August 15, 2024
Processing time: 105 Days and 20.8 Hours

Core Tip

Core Tip: For the first time, we found that lecithin-cholesterol acyltransferase, a molecule related to lipid metabolism, is closely related to the metastasis of hepatocellular carcinoma (HCC), which provides a new prospective for studying the recurrence and metastasis mechanism of HCC, and also finds strong evidence for revealing the connection between lipid metabolism and HCC metastasis.