Basic Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3559-3584
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3559
Expression and significant roles of the long non-coding RNA CASC19/miR-491-5p/HMGA2 axis in the development of gastric cancer
Li-Xiang Zhang, Pan-Quan Luo, Zhi-Jian Wei, A-Man Xu, Tao Guo
Li-Xiang Zhang, Department of Gastroenterology, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China
Li-Xiang Zhang, Anhui Provincial Key Laboratory of Digestive Disease, Hefei 230031, Anhui Province, China
Pan-Quan Luo, Zhi-Jian Wei, A-Man Xu, Tao Guo, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Hefei 230031, Anhui Province, China
Tao Guo, Anhui Public Health Clinical Center, Hefei 230000, Anhui Province, China
Co-first authors: Li-Xiang Zhang and Pan-Quan Luo.
Co-corresponding authors: Tao Guo and A-Man Xu.
Author contributions: Zhang LX write the main work; Luo PQ helped finish the experiments and write the manuscript; Xu AM designed this study; Wei ZJ and Guo T revised this manuscript; Zhang LX and Luo PQ contribute this work equally as co-first author; Xu AM and Guo T contribute this work equally as co-corresponding authors; all authors read and approved the final manuscript.
Supported by Natural Science Foundation of Anhui Province, No. 2108085QH337; Research Fund of Anhui Medical University, No. 2022xkj156; Key Projects of Anhui Provincial Department of Education, No. 2023AH053330; and Anhui Institute of Translational Medicine Research Fund, No. 2022zhyx-C88.
Institutional review board statement: This study was approved by Institutional Review Board of the First Affiliated Hospital of Anhui Medical University.
Institutional animal care and use committee statement: The studies involving animals were reviewed and approved by the Ethics Committee of the Anhui Medical University.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: The data used to support the findings of this study are available from the corresponding author upon request.
ARRIVE guidelines statement: The authors have read the ARRIVE guidelines, and the manuscript was prepared and revised according to the ARRIVE guidelines.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Tao Guo, PhD, Professor, Department of General Surgery, The First Affiliated Hospital of Anhui Medical University, Shushan Street, Hefei 230031, Anhui Province, China. ahguotao@163.com
Received: December 20, 2023
Revised: April 25, 2024
Accepted: June 12, 2024
Published online: August 15, 2024
Processing time: 231 Days and 12.5 Hours
Core Tip

Core Tip: Gastric cancer (GC) is a common malignant tumor, long non-coding RNA and microRNA are important regulators that affect tumor proliferation, metastasis and chemotherapy resistance, and thus participate in tumor progression, this study aim to explore the role of CASC19/miR-491-5p/HMGA2 regulatory axis in GC, this article verify that CASC19 may promote the progression of GC by regulating the miR-491-5p/HMGA2 signal axis, which can be helpful for the diagnosis and treatment of GC.