Editorial
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2024; 16(8): 3376-3381
Published online Aug 15, 2024. doi: 10.4251/wjgo.v16.i8.3376
Navigating the labyrinth of long non-coding RNAs in colorectal cancer: From chemoresistance to autophagy
Jia-Mei Yu, Chong-Qi Sun, Huan-Huan Xu, Ya-Li Jiang, Xing-Yu Jiang, Si-Qi Ni, Ting-Yu Zhao, Ling-Xiang Liu
Jia-Mei Yu, Chong-Qi Sun, Xing-Yu Jiang, Si-Qi Ni, Ting-Yu Zhao, Ling-Xiang Liu, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, Jiangsu Province, China
Huan-Huan Xu, Department of Hematology and Oncology, Department of Geriatric Lung Cancer Research Laboratory, Jiangsu Province Geriatric Hospital, Nanjing 210009, Jiangsu Province, China
Ya-Li Jiang, Central Laboratory, The Friendship Hospital of Ili Kazakh Autonomous Prefecture, Ili & Jiangsu Joint Institute of Health, Yining 835000, Xinjiang Uyghur Autonomous Region, China
Co-first authors: Jia-Mei Yu and Chong-Qi Sun.
Author contributions: Yu JM, Sun CQ, and Liu LX contributed to this paper; Yu JM, Sun CQ, Xu HH, Jiang YL, and Liu LX designed the overall concept and outline of the manuscript; Yu JM, Sun CQ, Jiang XY, Ni SQ, Zhao TY, and Liu LX contributed to the discussion and design of the manuscript; Yu JM and Sun CQ contributed to the writing, and editing the manuscript, illustrations, and review of literature; and all authors read and approved the final manuscript.
Supported by the National Natural Science Foundation of China, No. 81472782; National Clinical Key Specialty Department (Oncology) of China, No. YWC-ZKJS-2023-01; and Research Fund of Yili Institute of Clinical Medicine, No. yl2021ms02.
Conflict-of-interest statement: The authors declare no conflicts of interest.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ling-Xiang Liu, MD, PhD, Professor, Department of Oncology, The First Affiliated Hospital of Nanjing Medical University, No. 300 Guangzhou Road, Nanjing 210029, Jiangsu Province, China. llxlau@163.com
Received: March 6, 2024
Revised: May 3, 2024
Accepted: May 22, 2024
Published online: August 15, 2024
Processing time: 154 Days and 16.6 Hours
Core Tip

Core Tip: Long non-coding RNAs (lncRNAs) expression can regulate both autophagy and chemoresistance in colorectal cancer (CRC). Autophagy exerts dual effects on chemotherapy resistance through multiple mechanisms, including the regulation of autophagy-related lncRNAs. In this editorial, we focus on the role of lncRNAs in the regulation of autophagy and chemoresistance in CRC and explore the feasibility of modulating chemosensitivity by interfering with lncRNAs involved in the autophagic process.