Case Report
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Feb 15, 2024; 16(2): 550-556
Published online Feb 15, 2024. doi: 10.4251/wjgo.v16.i2.550
Hepatomegaly and jaundice as the presenting symptoms of systemic light-chain amyloidosis: A case report
Xu Zhang, Fei Tang, Yan-Ying Gao, De-Zhao Song, Jing Liang
Xu Zhang, Fei Tang, Yan-Ying Gao, Jing Liang, Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, Tianjin 300170, China
Xu Zhang, Fei Tang, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Artificial Cell Engineering Technology Research Center, Tianjin Institute of Hepatobiliary Disease, Tianjin 300170, China
De-Zhao Song, Department of Interventional Radiology, The Third Central Hospital of Tianjin, Tianjin 300170, China
Co-first authors: Xu Zhang and Fei Tang.
Author contributions: Zhang X and Tang F contributed to the writing-original draft preparation; Gao YY and Song DZ contributed to the patient diagnosis and treatment; Song DZ contributed to the performing transjugular liver biopsy and balloon dilatation of the hepatic vein; Liang J contributed to the writing-reviewing and editing; Zhang X and Tang F contributed equally to this work as co-first authors; All authors have read and approve the final manuscript.
Supported by Tianjin Key Medical Discipline (Specialty) Construction Project, No. TJYXZDXK-034A.
Informed consent statement: The patient provided informed written consent prior to this manuscript.
Conflict-of-interest statement: The authors declare no conflict of interest.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jing Liang, MD, Chief Physician, Department of Gastroenterology and Hepatology, The Third Central Hospital of Tianjin, No. 83 Jintang Road, Tianjin 300170, China. haolele77@sina.com
Received: October 1, 2023
Peer-review started: October 1, 2023
First decision: December 5, 2023
Revised: December 11, 2023
Accepted: December 26, 2023
Article in press: December 26, 2023
Published online: February 15, 2024
Processing time: 123 Days and 19.4 Hours
Core Tip

Core Tip: Light chain (AL) amyloidosis is a systemic disease, with heart, kidneys, and peripheral nerves being the most commonly affected organs. The proportion of patients with only liver involvement alone is quite low, and these patients are highly prone to misdiagnosis and missed diagnosis. We present a case of AL amyloidosis with isolated liver involvement and severe cholestasis as the predominant manifestations.