Retrospective Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4675-4684
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4675
Temozolomide and capecitabine regimen as first-line treatment in advanced gastroenteropancreatic neuroendocrine tumors at a Latin American reference center
Wagner Eduardo Cruz-Diaz, Victor Paitan, Jersinho Medina, Raymundo Flores, Juan Haro-Varas, Raul Mantilla, Victor Castro-Oliden
Wagner Eduardo Cruz-Diaz, Victor Paitan, Juan Haro-Varas, Raul Mantilla, Victor Castro-Oliden, Department of Oncology, Instituto Nacional de Enfermedades Neoplásicas, Lima 15038, Perú
Jersinho Medina, Department of Pathology, Instituto Nacional de Enfermedades Neoplásicas, Lima 15038, Perú
Raymundo Flores, Department of Radiology, Instituto Nacional de Enfermedades Neoplásicas, Lima 15038, Perú
Author contributions: Cruz-Diaz WE collected the data at the Instituto Nacional de Enfermedades Neoplásicas and wrote the initial manuscript; Paitan V and Haro-Varas J supervised the initial manuscript; Medina J reviewed the pathology slides, and Flores R reviewed the computed tomography and magnetic resonance imaging images; Mantilla R was responsible for conducting the statistical analysis, and Castro-Oliden V provided expert guidance and supervision throughout the study and critically reviewed the final manuscript; All authors read and approved the final manuscript.
Institutional review board statement: Approved by the Research Protocol Review Committee of Instituto Nacional de Enfermedades Neoplásicas, No. INEN 24-61.
Informed consent statement: The need for patient consent was waived due to the retrospective nature of the study.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Data sharing statement: No additional data are available.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Wagner Eduardo Cruz-Diaz, MD, Staff Physician, Department of Oncology, Instituto Nacional de Enfermedades Neoplásicas, Avenue Angamos Este 2520, Surquillo, Lima 15038, Peru. wagner.cruz@upch.pe
Received: July 22, 2024
Revised: August 31, 2024
Accepted: September 19, 2024
Published online: December 15, 2024
Processing time: 113 Days and 14.2 Hours
Core Tip

Core Tip: In this study, patients diagnosed with advanced gastroenteropancreatic neuroendocrine tumors who were treated with the temozolomide and capecitabine regimen exhibited a median overall survival of 49 months, with 42% surviving at 60 months. The regimen was well-tolerated, and most patients experienced stable disease. These findings suggest that this treatment could be viable in settings where standard therapies are unavailable or inaccessible, although further prospective studies are needed for confirmation.