Retrospective Cohort Study
Copyright ©The Author(s) 2024. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Dec 15, 2024; 16(12): 4614-4624
Published online Dec 15, 2024. doi: 10.4251/wjgo.v16.i12.4614
Local excision for middle-low rectal cancer after neoadjuvant chemoradiation: A retrospective study from a single tertiary center
Nan Chen, Chang-Long Li, Lin Wang, Yun-Feng Yao, Yi-Fan Peng, Tian-Cheng Zhan, Jun Zhao, Ai-Wen Wu
Nan Chen, Chang-Long Li, Lin Wang, Yun-Feng Yao, Yi-Fan Peng, Tian-Cheng Zhan, Jun Zhao, Ai-Wen Wu, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, Beijing 100142, China
Co-first authors: Nan Chen and Chang-Long Li.
Author contributions: Chen N and Li CL performed the data collection and analysis, and wrote the paper; Chen N, Wang L, Yao YF, Peng YF, Zhan TC, Zhao J and Wu AW helped the recruitment of patients; Wu AW designed study.
Supported by Beijing Municipal Administration of Hospitals Incubating Program, No. PZ2020027; Beijing Talent Incubating Funding, No. 2019-4; National Natural Science Foundation of China, No. 81773214; Beijing Hospitals Authority Clinical Medicine Development of Special Funding Support, No. ZYLX202116; National Key R and D Program of China, No. 2021YFF1201104; 2019 Major and Difficult Diseases Chinese and Western Medicine Coordination Capacity Colorectal Cancer Project, No. (2018) 275; Science Foundation of Peking University Cancer Hospital-2023, No. JC202310; and Natural Science Project of Chifeng City, No. 2023-114.
Institutional review board statement: The study was approved by the medical ethics committee of the Peking University Cancer Hospital, and informed consent was waived (2015KT31/2017KT104).
Informed consent statement: All study participants, or their legal guardian, provided informed written consent prior to study enrollment.
Conflict-of-interest statement: All authors declare no conflict of interest.
Data sharing statement: No additional data are available.
STROBE statement: The authors have read the STROBE Statement—checklist of items, and the manuscript was prepared and revised according to the STROBE Statement—checklist of items.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ai-Wen Wu, MD, PhD, Professor, Key Laboratory of Carcinogenesis and Translational Research (Ministry of Education/Beijing), Gastrointestinal Center, Unit III, Peking University Cancer Hospital and Institute, No. 52 Fucheng Road, Haidian District, Beijing 100142, China. wuaw@sina.com
Received: July 23, 2024
Revised: August 13, 2024
Accepted: September 5, 2024
Published online: December 15, 2024
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Core Tip

Core Tip: This retrospective study explores the safety, efficacy, and long-term prognosis of local excision (LE) in patients with middle-low rectal cancer who responded well to neoadjuvant chemoradiotherapy. The findings demonstrate that LE can achieve high rates of organ preservation and favorable oncological outcomes, including a 5-year disease-free survival rate of 88.4% and overall survival rate of 92.9%. Complications were manageable and non-severe. This study supports the potential of minimally invasive treatments in selected patients, highlighting the importance of patient participation in treatment decisions.