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©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2023; 15(8): 1497-1504
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1497
Published online Aug 15, 2023. doi: 10.4251/wjgo.v15.i8.1497
Gastric neuroendocrine tumors in a BRCA2 germline mutation carrier: A case report
Hui-Fang Zhang, Yi Zheng, Xue Wen, Jing Zhao, Jun Li, Department of Pathology, The First Affiliated Hospital, Medical College, Zhejiang University, Hangzhou 310000, Zhejiang Province, China
Author contributions: Li J designed and wrote the case report and performed the literature search; Zhang HF, Zhen Y, and Wen X assisted in the literature search and wrote the paper; Zhao J participated in the data acquisition and analysis.
Supported by Natural Science Foundation of Zhejiang Province , No. LQ20H1600036 (to Wen X) .
Informed consent statement: Informed written consent was obtained from the patient for the publication of this report.
Conflict-of-interest statement: No competing financial interests exist.
CARE Checklist (2016) statement: The authors have read the CARE Checklist (2016), and the manuscript was prepared and revised according to the CARE Checklist (2016).
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Jun Li, Doctor, Chief Physician, Department of Pathology, The First Affiliated Hospital, Medical College, Zhejiang University, No. 79 Qingchun Road, Hangzhou 310000, Zhejiang Province, China. 1101025@zju.edu.cn
Received: April 8, 2023
Peer-review started: April 8, 2023
First decision: May 27, 2023
Revised: June 7, 2023
Accepted: July 18, 2023
Article in press: July 18, 2023
Published online: August 15, 2023
Processing time: 123 Days and 21 Hours
Peer-review started: April 8, 2023
First decision: May 27, 2023
Revised: June 7, 2023
Accepted: July 18, 2023
Article in press: July 18, 2023
Published online: August 15, 2023
Processing time: 123 Days and 21 Hours
Core Tip
Core Tip: Type 1 enterochromaffin-like neuroendocrine tumors (ECL-cell NETs) occur most frequently and are associated with autoimmune gastritis. In gastric neuroendocrine tumors, molecular changes occur in genes including MEN1, CDKN1B, P27, and ATP4A. This is the first report of type 1 ECL-cell NETs with a pathogenic germline mutation of the BRCA2 gene.