Ren S, Guo K, Li Y, Cao YY, Wang ZQ, Tian Y. Diagnostic accuracy of apparent diffusion coefficient to differentiate intrapancreatic accessory spleen from pancreatic neuroendocrine tumors. World J Gastrointest Oncol 2023; 15(6): 1051-1061 [PMID: 37389113 DOI: 10.4251/wjgo.v15.i6.1051]
Corresponding Author of This Article
Zhong-Qiu Wang, MD, PhD, Chief Doctor, Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. zhongqiuwang0815@163.com
Research Domain of This Article
Oncology
Article-Type of This Article
Retrospective Study
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Ren S, Guo K, Li Y, Cao YY, Wang ZQ, Tian Y. Diagnostic accuracy of apparent diffusion coefficient to differentiate intrapancreatic accessory spleen from pancreatic neuroendocrine tumors. World J Gastrointest Oncol 2023; 15(6): 1051-1061 [PMID: 37389113 DOI: 10.4251/wjgo.v15.i6.1051]
Shuai Ren, Kai Guo, Yuan Li, Ying-Ying Cao, Zhong-Qiu Wang, Ying Tian, Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, Nanjing 210029, Jiangsu Province, China
Author contributions: Ren S, Guo K, and Li Y contributed equally to this work; Ren S, Wang ZQ, and Tian Y designed the research study; Ren S, Guo K, Li Y, and Cao YY performed the research; Ren S, Guo K, and Li Y analyzed the data; Ren S wrote the manuscript; Wang ZQ and Tian Y revised the manuscript; All authors read and approved the final manuscript.
Supported bythe National Natural Science foundation of China, No. 82202135, and No. 82171925; Foundation of Excellent Young Doctor of Jiangsu Province Hospital of Chinese Medicine, No. 2023QB0112; Innovative Development Foundation of Department in Jiangsu Hospital of Chinese Medicine, No. Y2021CX19; and Developing Program for High-level Academic Talent in Jiangsu Hospital of TCM, No. y2021rc03.
Institutional review board statement: The study was reviewed and approved by the ethics committee of Affiliated Hospital of Nanjing University of Chinese Medicine (Approval No. 2017NL-137-05).
Informed consent statement: Informed consent statement was waived due to the retrospective nature of the study.
Conflict-of-interest statement: The authors declare that they have no conflicts of interest.
Data sharing statement: Patient imaging data and histopathology reports contain sensitive patient information and cannot be released publicly due to the legal and ethical restrictions imposed by the institutional ethics committee (Affiliated Hospital of Nanjing University of Chinese Medicine). Data is available upon reasonable request from the following e-mail address: zhongqiuwang@njucm.edu.cn.
Corresponding author: Zhong-Qiu Wang, MD, PhD, Chief Doctor, Department of Radiology, Jiangsu Province Hospital of Chinese Medicine, Affiliated Hospital of Nanjing University of Chinese Medicine, No. 155 Hanzhong Road, Nanjing 210029, Jiangsu Province, China. zhongqiuwang0815@163.com
Received: December 30, 2022 Peer-review started: December 30, 2022 First decision: January 22, 2023 Revised: February 1, 2023 Accepted: April 19, 2023 Article in press: April 19, 2023 Published online: June 15, 2023 Processing time: 167 Days and 0.2 Hours
Core Tip
Core Tip: Intrapancreatic accessory spleen (IPAS) presents as a solitary, well-defined, hypervascular mass on contrast-enhanced computed tomography or contrast-enhanced magnetic resonance imaging. They are often misdiagnosed as small (< 3 cm) hypervascular pancreatic neuroendocrine tumors (PNETs). IPAS is innocuous in nature and does not require treatment. However, surgery and/or chemotherapy are recommended for PNETs. The overlap of imaging characteristics between IPAS and PNETs often requires surgical management. Therefore, preoperative characterization is of utmost importance. Our study demonstrated that both absolute apparent diffusion coefficient (ADC) and normalized ADC values (lesion-to-spleen ADC ratios) allow clinically relevant differentiation of IPAS from PNET.
