Review
Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Apr 15, 2023; 15(4): 596-616
Published online Apr 15, 2023. doi: 10.4251/wjgo.v15.i4.596
Role of tumor-associated macrophages in common digestive system malignant tumors
Yue Shen, Jia-Xi Chen, Ming Li, Ze Xiang, Jian Wu, Yi-Jin Wang
Yue Shen, Department of Dermatology, Suzhou Municipal Hospital, Suzhou 215008, Jiangsu Province, China
Jia-Xi Chen, Ze Xiang, School of Medicine, Zhejiang University, Hangzhou 310009, Zhejiang Province, China
Ming Li, Department of Pathology, Suzhou Municipal Hospital, Suzhou 215008, Jiangsu Province, China
Jian Wu, Department of Clinical Laboratory, Suzhou Municipal Hospital, Suzhou 215008, Jiangsu Province, China
Yi-Jin Wang, School of Medicine, Southern University of Science and Technology, Shenzhen 518055, Guangdong Province, China
Author contributions: Wu J and Wang Y designed study, revised the manuscript, reviewed the results and made critical comments on the manuscript; Shen Y, and Chen JX analyzed data and performed manuscript drafting; Li M and Xiang Z searched the literature and collected data; All authors reviewed and approved the final version; Shen Y and Chen JX contributed equally to this work; Wu J and Wang Y contributed equally to this work.
Supported by National Natural Science Foundation of China, No. 82272396; Suzhou Medical and Health Science and Technology Innovation Project, No. SKY2022057; and The Youth Medical Talent of Jiangsu Province, No. QNRC2016475.
Conflict-of-interest statement: All the authors report no relevant conflicts of interest for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Yi-Jin Wang, MD, PhD, Professor, School of Medicine, Southern University of Science and Technology, No. 1088 Xueyuan Avenue, Nanshan, Shenzhen 518055, Guangdong Province, China. wangyj3@sustech.edu.cn
Received: November 19, 2022
Peer-review started: November 19, 2022
First decision: January 9, 2023
Revised: February 12, 2023
Accepted: March 30, 2023
Article in press: March 30, 2023
Published online: April 15, 2023
Processing time: 143 Days and 23.7 Hours
Core Tip

Core Tip: This review summarizes the role of tumor-associated macrophages (TAMs) in common digestive system malignant tumors, including esophageal, gastric, colorectal, pancreatic and liver cancers. How TAMs promote the development of tumors, and how they act as potential therapeutic targets and their clinical applications are also described.