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Copyright ©The Author(s) 2023. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Jan 15, 2023; 15(1): 1-18
Published online Jan 15, 2023. doi: 10.4251/wjgo.v15.i1.1
Combining local regional therapy and systemic therapy: Expected changes in the treatment landscape of recurrent hepatocellular carcinoma
Jing Liang, Yi Bai, Fu-Shuang Ha, Ying Luo, Hui-Ting Deng, Ying-Tang Gao
Jing Liang, Fu-Shuang Ha, Department of Hepatology, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Nankai University Affiliated Third Center Hospital, Tianjin 300170, China
Yi Bai, Department of Hepatobiliary Surgery, Tianjin First Central Hospital, Tianjin 300192, China
Ying Luo, Hui-Ting Deng, Ying-Tang Gao, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Nankai University Affiliated Third Center Hospital, Tianjin 300170, China
Ying-Tang Gao, Tianjin Institute of Hepatobiliary Disease, The Third Central Clinical College of Tianjin Medical University, Tianjin 300170, China
Author contributions: Liang J and Bai Y contributed equally to this work; Liang J and Bai Y wrote the paper; Ha FS, Luo Y, and Deng HT collected the literature and data; Gao YT revised the paper; all authors read and approved the final manuscript.
Supported by the Natural Science Foundation of Tianjin Science and Technology Bureau, China, No. 21JCZDJC01050; Tianjin Key Medical Discipline (Specialty) Construction Project, No. TJYXZDXK-034A; and Tianjin Municipal Health Science and Technology Project, No. TJWJ2021ZD003, No. KJ20068, No. KJ20129, and No. TJWJ2022XK029.
Conflict-of-interest statement: Authors declare no conflict of interests for this article.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Ying-Tang Gao, PhD, Professor, Tianjin Key Laboratory of Extracorporeal Life Support for Critical Diseases, Nankai University Affiliated Third Center Hospital, No. 83 Jintang Road, Hedong District, Tianjin 300170, China. gaoyt816@163.com
Received: September 24, 2022
Peer-review started: September 24, 2022
First decision: November 15, 2022
Revised: December 6, 2022
Accepted: December 27, 2022
Article in press: December 27, 2022
Published online: January 15, 2023
Processing time: 107 Days and 17.9 Hours
Core Tip

Core Tip: Hepatocellular carcinoma (HCC) is a highly recurrent malignancy; at present, there is a lack of definite treatment strategies for recurrent HCC. Recurrent HCC has particularities in recurrence mode and tumor microenvironment, so its treatment strategy should be different from that of primary HCC. Systemic therapy based on the immune microenvironment has emerged as a potential alternative treatment option for advanced HCC. Combining local therapy and systemic therapy for recurrent HCC may achieve better effects and is worthy of further exploration.