Letter to the Editor
Copyright ©The Author(s) 2022. Published by Baishideng Publishing Group Inc. All rights reserved.
World J Gastrointest Oncol. Aug 15, 2022; 14(8): 1600-1603
Published online Aug 15, 2022. doi: 10.4251/wjgo.v14.i8.1600
Acute or chronic inflammation role in gastrointestinal oncology
Hong-Jin Chen, Gui-You Liang, Xiong Chen, Zhou Du
Hong-Jin Chen, Gui-You Liang, Translational Medicine Research Center, Guizhou Medical University, Guiyang 550025, Guizhou Province, China
Hong-Jin Chen, Guizhou Institute of Precision Medicine, Affiliated Hospital of Guizhou Medical University, Guiyang 550009, Guizhou Province, China
Xiong Chen, Department of Endocrinology, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Zhou Du, Department of Hernia and Abdominal Wall Surgery, The First Affiliated Hospital of Wenzhou Medical University, Wenzhou 325000, Zhejiang Province, China
Author contributions: Chen HJ and Chen X designed the research; Chen HJ wrote this comment; Liang GY and Du Z reviewed and supervised this manuscript; All authors approved the final version of the article.
Supported by the Start-up Fund of Guizhou Medical University, No. J2021032; the Postdoctoral Research Fund of Affiliated Hospital of Guizhou Medical University, No. BSH-Q-2021-10; and the Guizhou Provincial Health Commission, No. gzwkj2022-082.
Conflict-of-interest statement: All authors have nothing to disclose.
Open-Access: This article is an open-access article that was selected by an in-house editor and fully peer-reviewed by external reviewers. It is distributed in accordance with the Creative Commons Attribution NonCommercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited and the use is non-commercial. See: https://creativecommons.org/Licenses/by-nc/4.0/
Corresponding author: Zhou Du, MD, Chief Doctor, Department of Hernia and Abdominal Wall Surgery, The First Affiliated Hospital of Wenzhou Medical University, Shangcai Village, Nanbaixiang, Wenzhou 325000, Zhejiang Province, China. duzhou2190@126.com
Received: April 4, 2022
Peer-review started: April 4, 2022
First decision: May 11, 2022
Revised: June 2, 2022
Accepted: July 16, 2022
Article in press: July 16, 2022
Published online: August 15, 2022
Processing time: 128 Days and 0.5 Hours
Core Tip

Core Tip: Gastrointestinal cancers are systematic tumors with the largest number of patients in the world. Most patients are prone to migration, invasion or other malignant phenotypes. The treatment strategies mainly include surgical resection, radiotherapy and chemotherapy in clinic. However, the survival rate of cases still cannot be significantly improved. Recently, the relationship between inflammation and gastrointestinal tumors has been gradually clarified, and chronic inflammation plays an important role in the occurrence and deterioration of tumors. The main purpose of this letter is to illustrate the key role of inflammation in tumor progression and potential therapeutic directions.